The aim of the present study is to investigate the synergic role of68Ga-PSMA PET/MRI and68Ga-DOTA-RM2 PET/MRI in prostate cancer (PCa) staging. We present pilot data on twenty-two patients with biopsy-proven PCa that underwent68Ga-PSMA PET/MRI for staging purposes, with 19/22 also undergoing68Gaa-DOTA-RM2 PET/MRI. TNM classification based on image findings was performed and quantitative imaging parameters were collected for each scan. Furthermore, twelve patients underwent radical prostatectomy with the availability of histological data that were used as the gold standard to validate intraprostatic findings. A DICE score between regions of interest manually segmented on the primary tumour on68Ga-PSMA PET,68Ga-DOTA-RM2 PET and on T2 MRI was computed. All imaging modalities detected the primary PCa in 18/19 patients, with68Ga-DOTA-RM2 PET not detecting any lesion in 1/19 patients. In the remaining patients,68Ga-PSMA and MRI were concordant. Seven patients presented seminal vesicles involvement on MRI, with two of these being also detected by68Ga-PSMA, and68Ga-DOTA-RM2 PET being negative. Regarding extraprostatic disease,68Ga-PSMA PET,68Ga-DOTA-RM2 PET and MRI resulted positive in seven, four and five patients at lymph-nodal level, respectively, and at a bone level in three, zero and one patients, respectively. These preliminary results suggest the potential complementary role of68Ga-PSMA PET,68Ga-DOTA-RM2 PET and MRI in PCa characterization during the staging phase.

Mapelli, P., Ghezzo, S., Samanes Gajate, A., Preza, E., Brembilla, G., Cucchiara, V., et al. (2021). Preliminary results of an ongoing prospective clinical trial on the use of68ga-psma and68ga-dota-rm2 pet/mri in staging of high-risk prostate cancer patients. DIAGNOSTICS, 11(11) [10.3390/diagnostics11112068].

Preliminary results of an ongoing prospective clinical trial on the use of68ga-psma and68ga-dota-rm2 pet/mri in staging of high-risk prostate cancer patients

Presotto L.;
2021

Abstract

The aim of the present study is to investigate the synergic role of68Ga-PSMA PET/MRI and68Ga-DOTA-RM2 PET/MRI in prostate cancer (PCa) staging. We present pilot data on twenty-two patients with biopsy-proven PCa that underwent68Ga-PSMA PET/MRI for staging purposes, with 19/22 also undergoing68Gaa-DOTA-RM2 PET/MRI. TNM classification based on image findings was performed and quantitative imaging parameters were collected for each scan. Furthermore, twelve patients underwent radical prostatectomy with the availability of histological data that were used as the gold standard to validate intraprostatic findings. A DICE score between regions of interest manually segmented on the primary tumour on68Ga-PSMA PET,68Ga-DOTA-RM2 PET and on T2 MRI was computed. All imaging modalities detected the primary PCa in 18/19 patients, with68Ga-DOTA-RM2 PET not detecting any lesion in 1/19 patients. In the remaining patients,68Ga-PSMA and MRI were concordant. Seven patients presented seminal vesicles involvement on MRI, with two of these being also detected by68Ga-PSMA, and68Ga-DOTA-RM2 PET being negative. Regarding extraprostatic disease,68Ga-PSMA PET,68Ga-DOTA-RM2 PET and MRI resulted positive in seven, four and five patients at lymph-nodal level, respectively, and at a bone level in three, zero and one patients, respectively. These preliminary results suggest the potential complementary role of68Ga-PSMA PET,68Ga-DOTA-RM2 PET and MRI in PCa characterization during the staging phase.
Articolo in rivista - Articolo scientifico
Hybrid imaging; Multimodal imaging; PET/MRI; Prostate cancer; PSMA; RM2;
English
Mapelli, P., Ghezzo, S., Samanes Gajate, A., Preza, E., Brembilla, G., Cucchiara, V., et al. (2021). Preliminary results of an ongoing prospective clinical trial on the use of68ga-psma and68ga-dota-rm2 pet/mri in staging of high-risk prostate cancer patients. DIAGNOSTICS, 11(11) [10.3390/diagnostics11112068].
Mapelli, P; Ghezzo, S; Samanes Gajate, A; Preza, E; Brembilla, G; Cucchiara, V; Ahmed, N; Bezzi, C; Presotto, L; Bettinardi, V; Savi, A; Magnani, P; Menichini, R; Coliva, A; Neri, I; Di Gaeta, E; Gianolli, L; Freschi, M; Briganti, A; De Cobelli, F; Scifo, P; Picchio, M
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/380434
Citazioni
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 5
Social impact