OBJECTIVES: To assess the relationship between the type of chronic liver diseases (CLDs), clinical severity and patients’ HRQoL. METHODS: A naturalistic, multicentre study has been conducting to identify and test quality of care indicators. Adult CLDs patients (age>18 years) have been enrolling at gastroenterology unit of 3 Italian hospitals. We are collecting socio-demographic, clinical and HRQoL data with the EQ-5D-3L. Patients are sub-grouped according to CLD type and to clinical severity using the modified Child-Turcotte-Pugh score: with this instrument, patients are classified as non-cirrhotic, early cirrhotic (class A), advanced cirrhotic (classes B and C). We conducted Kruskall-Wallis tests to assess relationship between EQ-5D-VAS score and disease type or severity score. RESULTS: Results are based on data from 2,221 patients (67% male, median age=62 years), classified into the following subgroups: HCV or HBV chronic hepatitis (36.0%), compensated cirrhosis (CC, 23.5%), hepatocellular carcinoma (HCC, 19.8%), decompensated cirrhosis (DC, 13.5%), patients in evaluation or listed for liver transplant (LT, 7.2%). Non-cirrhotic patients (HCV or HBV chronic hepatitis) had significantly (p<0.001) higher median VAS (80) than patients with any other CLD types (70). In contrast, patients listed for LT had the lowest (p<0.05) median VAS (65) and the highest proportion of patients (58.1%) in Child class B-C. DC patients had a median VAS not significantly different from that of HCC or CC patients (70 versus 70 and 73, respectively). On the other hand, DC patients in child class A showed a significantly (p<0.05) higher median VAS (72.5) than HCC and CC patients in class B-C, who had a median VAS of 70 and 60, respectively. CONCLUSIONS: HRQoL of CLDs patients is significantly related with the Child-Turcotte-Pugh severity score. These results could be useful to understand the impact of the disease severity on patients’ HRQoL and guide some decisions in clinical care

Scalone, L., Cortesi, P., Ciampichini, R., Okolicsanyi, S., Rota, M., Ciaccio, A., et al. (2012). PGI36 Relationship Between Clinical Severity and Health Related Quality of Life in Chronic Liver Diseases. VALUE IN HEALTH, 15(7), A332-A332 [10.1016/j.jval.2012.08.785].

PGI36 Relationship Between Clinical Severity and Health Related Quality of Life in Chronic Liver Diseases

SCALONE, LUCIANA;CORTESI, PAOLO ANGELO;OKOLICSANYI, STEFANO;ROTA, MATTEO;CIACCIO, ANTONIO;Colledan, M;CESANA, GIANCARLO;MANTOVANI, LORENZO GIOVANNI;STRAZZABOSCO, MARIO
2012

Abstract

OBJECTIVES: To assess the relationship between the type of chronic liver diseases (CLDs), clinical severity and patients’ HRQoL. METHODS: A naturalistic, multicentre study has been conducting to identify and test quality of care indicators. Adult CLDs patients (age>18 years) have been enrolling at gastroenterology unit of 3 Italian hospitals. We are collecting socio-demographic, clinical and HRQoL data with the EQ-5D-3L. Patients are sub-grouped according to CLD type and to clinical severity using the modified Child-Turcotte-Pugh score: with this instrument, patients are classified as non-cirrhotic, early cirrhotic (class A), advanced cirrhotic (classes B and C). We conducted Kruskall-Wallis tests to assess relationship between EQ-5D-VAS score and disease type or severity score. RESULTS: Results are based on data from 2,221 patients (67% male, median age=62 years), classified into the following subgroups: HCV or HBV chronic hepatitis (36.0%), compensated cirrhosis (CC, 23.5%), hepatocellular carcinoma (HCC, 19.8%), decompensated cirrhosis (DC, 13.5%), patients in evaluation or listed for liver transplant (LT, 7.2%). Non-cirrhotic patients (HCV or HBV chronic hepatitis) had significantly (p<0.001) higher median VAS (80) than patients with any other CLD types (70). In contrast, patients listed for LT had the lowest (p<0.05) median VAS (65) and the highest proportion of patients (58.1%) in Child class B-C. DC patients had a median VAS not significantly different from that of HCC or CC patients (70 versus 70 and 73, respectively). On the other hand, DC patients in child class A showed a significantly (p<0.05) higher median VAS (72.5) than HCC and CC patients in class B-C, who had a median VAS of 70 and 60, respectively. CONCLUSIONS: HRQoL of CLDs patients is significantly related with the Child-Turcotte-Pugh severity score. These results could be useful to understand the impact of the disease severity on patients’ HRQoL and guide some decisions in clinical care
Abstract in rivista
Health care indicators; Liver diseases; Quality of care
English
A332
A332
1
Scalone, L., Cortesi, P., Ciampichini, R., Okolicsanyi, S., Rota, M., Ciaccio, A., et al. (2012). PGI36 Relationship Between Clinical Severity and Health Related Quality of Life in Chronic Liver Diseases. VALUE IN HEALTH, 15(7), A332-A332 [10.1016/j.jval.2012.08.785].
Scalone, L; Cortesi, P; Ciampichini, R; Okolicsanyi, S; Rota, M; Ciaccio, A; Ideo, G; Colledan, M; Belli, L; Cesana, G; Mantovani, L; Strazzabosco, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/38039
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