The cerebral cortex gains its final configuration after complex mechanisms that take place during fetal life. Any derangement of this fine tuning, particularly in the early stages of cortical development, can determine structural alterations of the cortical mantle. Recent improvements of neuroradiological techniques have made it possible to diagnose in vivo human dysplastic lesions frequently associated with neurological deficits and epilepsy. In the first section of this review some aspects of normal cortical development are briefly outlined. In the second a survey of animal models presenting with cerebral malformations is given with particular reference to rats in which cortical abnormalities, induced by an alkylating agent, appear similar to those observed in humans. In the third part recent electroclinical, neuroradiological and neuropathological findings on epileptic patients presenting with neocortical structural alteration are reported
Spreafico, R., Battaglia, G., Franceschetti, S., Frassoni, C., Colacitti, C., Sancini, G., et al. (1997). Neuronal migration disorders (NMDs) in animal models and humans. In Molecular and Cellular Targets for Anti-Epileptic Drugs (pp. 119-128). London : JOHN LIBBEY & CO.
Neuronal migration disorders (NMDs) in animal models and humans
SANCINI, GIULIO ALFREDO;
1997
Abstract
The cerebral cortex gains its final configuration after complex mechanisms that take place during fetal life. Any derangement of this fine tuning, particularly in the early stages of cortical development, can determine structural alterations of the cortical mantle. Recent improvements of neuroradiological techniques have made it possible to diagnose in vivo human dysplastic lesions frequently associated with neurological deficits and epilepsy. In the first section of this review some aspects of normal cortical development are briefly outlined. In the second a survey of animal models presenting with cerebral malformations is given with particular reference to rats in which cortical abnormalities, induced by an alkylating agent, appear similar to those observed in humans. In the third part recent electroclinical, neuroradiological and neuropathological findings on epileptic patients presenting with neocortical structural alteration are reported
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