During early postnatal life neocortical neurons undergo significant maturational changes in passive membrane properties and active mechanisms, relevant to cell excitability. In rats the most significant changes occur during the first postnatal month. With respect to adults, immature pyramidal neurons have physiological properties supporting an increased excitability: less negative resting potential, higher input resistance, shorter electrotonic length, slower action potential repolarization, and lower efficiency in spike frequency adaptation. On the other hand, the inability to sustain long-lasting discharges, the less steep rising phase of the action potentials and the absence of intrinsically generated burst discharges may significantly affect the expression of cortical hyperexcitability, thus explaining the fragmentary and asynchronous characteristics of epileptic discharges in the immature brain

Franceschetti, S., Panzica, F., Sancini, G., & Avanzini, G. (1997). Postnatal neocortical development: maturational changes in the intrinsic properties of pyramidal neurons and their possible significance for epileptogenesis. In G. Avanzini, G. Regesta, P. Tanganelli, & M. Avoli (a cura di), Molecular and Cellular Targets for Anti-Epileptic Drugs (pp. 79-90). LONDON : JOHN LIBBEY & COMPANY LTD.

Postnatal neocortical development: maturational changes in the intrinsic properties of pyramidal neurons and their possible significance for epileptogenesis

Sancini, G;
1997

Abstract

During early postnatal life neocortical neurons undergo significant maturational changes in passive membrane properties and active mechanisms, relevant to cell excitability. In rats the most significant changes occur during the first postnatal month. With respect to adults, immature pyramidal neurons have physiological properties supporting an increased excitability: less negative resting potential, higher input resistance, shorter electrotonic length, slower action potential repolarization, and lower efficiency in spike frequency adaptation. On the other hand, the inability to sustain long-lasting discharges, the less steep rising phase of the action potentials and the absence of intrinsically generated burst discharges may significantly affect the expression of cortical hyperexcitability, thus explaining the fragmentary and asynchronous characteristics of epileptic discharges in the immature brain
No
Scientifica
Capitolo o saggio
epileptogenesis, pyramidal neurones
English
Molecular and Cellular Targets for Anti-Epileptic Drugs
0-86196 554-X
Franceschetti, S., Panzica, F., Sancini, G., & Avanzini, G. (1997). Postnatal neocortical development: maturational changes in the intrinsic properties of pyramidal neurons and their possible significance for epileptogenesis. In G. Avanzini, G. Regesta, P. Tanganelli, & M. Avoli (a cura di), Molecular and Cellular Targets for Anti-Epileptic Drugs (pp. 79-90). LONDON : JOHN LIBBEY & COMPANY LTD.
Franceschetti, S; Panzica, F; Sancini, G; Avanzini, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/37753
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