To investigate a possible relationship between hepatitis C virus infection and cholestasis of pregnancy, we identified all cases of cholestasis of pregnancy (145/16,271) and hepatitis C virus infection (63/16,27 1) between January 1992 and December 1997. Serologic screening was performed universally. The rate of cholestasis of pregnancy was greater in women whose hepatitis C virus antibodies were positive rather than negative [15.9% (10/63) vs 0.8% (135/16,208), P < 0.0011. Among women with cholestasis of pregnancy, mean (standard deviation) gestational age at onset of symptoms and at delivery was significantly lower among women whose hepatitis C virus antibodies were positive compared with negative women: 28.9 (3.2) vs 34.3 (3-5) weeks, P < 0.001 and 36-3 (0.9) vs 37.0 (1-6) weeks, P= 0.03, respectively. These findings suggest that early Occurrence of cholestasis of pregnancy may be an indication for serologic testing for hepatitis C virus.
Locatelli, A., Roncaglia, N., Arreghini, A., Bellini, P., Vergani, P., Ghidini, A. (1999). Hepatitis C virus infection is associated with a higher incidence of cholestasis of pregnancy. BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 106(5), 498-500 [10.1111/j.1471-0528.1999.tb08305.x].
Hepatitis C virus infection is associated with a higher incidence of cholestasis of pregnancy
LOCATELLI, ANNA;VERGANI, PATRIZIA;
1999
Abstract
To investigate a possible relationship between hepatitis C virus infection and cholestasis of pregnancy, we identified all cases of cholestasis of pregnancy (145/16,271) and hepatitis C virus infection (63/16,27 1) between January 1992 and December 1997. Serologic screening was performed universally. The rate of cholestasis of pregnancy was greater in women whose hepatitis C virus antibodies were positive rather than negative [15.9% (10/63) vs 0.8% (135/16,208), P < 0.0011. Among women with cholestasis of pregnancy, mean (standard deviation) gestational age at onset of symptoms and at delivery was significantly lower among women whose hepatitis C virus antibodies were positive compared with negative women: 28.9 (3.2) vs 34.3 (3-5) weeks, P < 0.001 and 36-3 (0.9) vs 37.0 (1-6) weeks, P= 0.03, respectively. These findings suggest that early Occurrence of cholestasis of pregnancy may be an indication for serologic testing for hepatitis C virus.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.