Background: To determine diagnostic performance of non-invasive tests using invasive fractional flow reserve (FFR) as reference standard for coronary artery disease (CAD). Methods: Medline, Embase, and citations of articles, guidelines, and reviews for studies were used to compare non-invasive tests with invasive FFR for suspected CAD published through March 2017. Results: Seventy-seven studies met inclusion criteria. The diagnostic test with the highest sensitivity to detect a functionally significant coronary lesion was coronary computed tomography (CT) angiography [88%(85%–90%)], followed by FFR derived from coronary CT angiography (FFRCT) [85%(81%–88%)], positron emission tomography (PET) [85%(82%–88%)], stress cardiac magnetic resonance (stress CMR) [81%(79%–84%)], stress myocardial CT perfusion combined with coronary CT angiography [79%(74%–83%)], stress myocardial CT perfusion [77%(73%–80%)], stress echocardiography (Echo) [72%(64%–78%)] and stress single-photon emission computed tomography (SPECT) [64%(60%–68%)]. Specificity to rule out CAD was highest for stress myocardial CT perfusion added to coronary CT angiography [91%(88%–93%)], stress CMR [91%(90%–93%)], and PET [87%(86%–89%)]. Conclusion: A negative coronary CT angiography has a higher test performance than other index tests to exclude clinically-important CAD. A positive stress myocardial CT perfusion added to coronary CT angiography, stress cardiac MR, and PET have a higher test performance to identify patients requiring invasive coronary artery evaluation.

Pontone, G., Guaricci, A., Palmer, S., Andreini, D., Verdecchia, M., Fusini, L., et al. (2020). Diagnostic performance of non-invasive imaging for stable coronary artery disease: A meta-analysis. INTERNATIONAL JOURNAL OF CARDIOLOGY, 300, 276-281 [10.1016/j.ijcard.2019.10.046].

Diagnostic performance of non-invasive imaging for stable coronary artery disease: A meta-analysis

Muscogiuri, G;
2020

Abstract

Background: To determine diagnostic performance of non-invasive tests using invasive fractional flow reserve (FFR) as reference standard for coronary artery disease (CAD). Methods: Medline, Embase, and citations of articles, guidelines, and reviews for studies were used to compare non-invasive tests with invasive FFR for suspected CAD published through March 2017. Results: Seventy-seven studies met inclusion criteria. The diagnostic test with the highest sensitivity to detect a functionally significant coronary lesion was coronary computed tomography (CT) angiography [88%(85%–90%)], followed by FFR derived from coronary CT angiography (FFRCT) [85%(81%–88%)], positron emission tomography (PET) [85%(82%–88%)], stress cardiac magnetic resonance (stress CMR) [81%(79%–84%)], stress myocardial CT perfusion combined with coronary CT angiography [79%(74%–83%)], stress myocardial CT perfusion [77%(73%–80%)], stress echocardiography (Echo) [72%(64%–78%)] and stress single-photon emission computed tomography (SPECT) [64%(60%–68%)]. Specificity to rule out CAD was highest for stress myocardial CT perfusion added to coronary CT angiography [91%(88%–93%)], stress CMR [91%(90%–93%)], and PET [87%(86%–89%)]. Conclusion: A negative coronary CT angiography has a higher test performance than other index tests to exclude clinically-important CAD. A positive stress myocardial CT perfusion added to coronary CT angiography, stress cardiac MR, and PET have a higher test performance to identify patients requiring invasive coronary artery evaluation.
Articolo in rivista - Articolo scientifico
Coronary artery disease; Diagnostic pathway; Fractional flow reserve; Meta-analysis; Non-invasive test;
English
276
281
6
Pontone, G., Guaricci, A., Palmer, S., Andreini, D., Verdecchia, M., Fusini, L., et al. (2020). Diagnostic performance of non-invasive imaging for stable coronary artery disease: A meta-analysis. INTERNATIONAL JOURNAL OF CARDIOLOGY, 300, 276-281 [10.1016/j.ijcard.2019.10.046].
Pontone, G; Guaricci, A; Palmer, S; Andreini, D; Verdecchia, M; Fusini, L; Lorenzoni, V; Guglielmo, M; Muscogiuri, G; Baggiano, A; Rabbat, M; Cademartiri, F; Strippoli, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/377123
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