PURPOSE: The aim of this study was to investigate the role of 18F-FDG PET/CT in predicting pathological prognostic factors, including tumor type and International Federation of Gynecology and Obstetrics (FIGO) score, in gestational trophoblastic disease (GTD). METHODS: Retrospective monocentric study including 24 consecutive patients who underwent to 18F-FDG PET/CT from May 2005 to March 2021 for GTD staging purpose. The following semiquantitative PET parameters were measured from the primary tumor and used for the analysis: maximum standardized uptake value (SUVmax), SUVmean, metabolic tumor volume (MTV) and total lesion glycolisis (TLG). Statistical analysis included Spearman correlation coefficient to evaluate the correlations between imaging parameters and tumor type (nonmolar trophoblastic vs postmolar trophoblastic tumors) and risk groups (high vs low, defined according to the FIGO score), whereas area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to assess the predictive value of the PET parameters. Mann-Whitney U test was used to further describe the parameter's potential in differentiating the populations. RESULTS: SUVmax and SUVmean resulted fair (AUC, 0.783; 95% confidence interval [CI], 0.56-0.95) and good (AUC, 0.811; 95% CI, 0.59-0.97) predictors of tumor type, respectively, showing a low (ρ = 0.489, adjusted P = 0.030) and moderate (ρ = 0.538, adjusted P = 0.027) correlation. According to FIGO score, TLG was instead a fair predictor (AUC, 0.770; 95% CI, 0.50-0.99) for patient risk stratification. CONCLUSIONS: 18F-FDG PET parameters have a role in predicting GTD pathological prognostic factors, with SUVmax and SUVmean being predictive for tumor type and TLG for risk stratification.

Bezzi, C., Monaco, L., Ghezzo, S., Mathoux, G., Bergamini, A., Zambella, E., et al. (2022). 18F-FDG PET/CT May Predict Tumor Type and Risk Score in Gestational Trophoblastic Disease. CLINICAL NUCLEAR MEDICINE, 47(6), 525-531 [10.1097/RLU.0000000000004135].

18F-FDG PET/CT May Predict Tumor Type and Risk Score in Gestational Trophoblastic Disease

Monaco, L;Mathoux, G;Presotto, L;Mangili, G;Cioffi, R;Mapelli, P;
2022

Abstract

PURPOSE: The aim of this study was to investigate the role of 18F-FDG PET/CT in predicting pathological prognostic factors, including tumor type and International Federation of Gynecology and Obstetrics (FIGO) score, in gestational trophoblastic disease (GTD). METHODS: Retrospective monocentric study including 24 consecutive patients who underwent to 18F-FDG PET/CT from May 2005 to March 2021 for GTD staging purpose. The following semiquantitative PET parameters were measured from the primary tumor and used for the analysis: maximum standardized uptake value (SUVmax), SUVmean, metabolic tumor volume (MTV) and total lesion glycolisis (TLG). Statistical analysis included Spearman correlation coefficient to evaluate the correlations between imaging parameters and tumor type (nonmolar trophoblastic vs postmolar trophoblastic tumors) and risk groups (high vs low, defined according to the FIGO score), whereas area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to assess the predictive value of the PET parameters. Mann-Whitney U test was used to further describe the parameter's potential in differentiating the populations. RESULTS: SUVmax and SUVmean resulted fair (AUC, 0.783; 95% confidence interval [CI], 0.56-0.95) and good (AUC, 0.811; 95% CI, 0.59-0.97) predictors of tumor type, respectively, showing a low (ρ = 0.489, adjusted P = 0.030) and moderate (ρ = 0.538, adjusted P = 0.027) correlation. According to FIGO score, TLG was instead a fair predictor (AUC, 0.770; 95% CI, 0.50-0.99) for patient risk stratification. CONCLUSIONS: 18F-FDG PET parameters have a role in predicting GTD pathological prognostic factors, with SUVmax and SUVmean being predictive for tumor type and TLG for risk stratification.
Articolo in rivista - Articolo scientifico
Scientifica
gestational trophoblastic disease; positron emission tomography; PET; CT; F-18-FDG; predictive value; pelvic malignancies; Female; Fluorodeoxyglucose F18; Humans; Positron Emission Tomography Computed Tomography; Pregnancy; Prognosis; Retrospective Studies; Risk Factors; Tumor Burden; Gestational Trophoblastic Disease; Neoplasms
English
Bezzi, C., Monaco, L., Ghezzo, S., Mathoux, G., Bergamini, A., Zambella, E., et al. (2022). 18F-FDG PET/CT May Predict Tumor Type and Risk Score in Gestational Trophoblastic Disease. CLINICAL NUCLEAR MEDICINE, 47(6), 525-531 [10.1097/RLU.0000000000004135].
Bezzi, C; Monaco, L; Ghezzo, S; Mathoux, G; Bergamini, A; Zambella, E; Fallanca, F; Samanes Gajate, A; Presotto, L; Sabetta, G; Mangili, G; Cioffi, R; Bettinardi, V; Gianolli, L; Mapelli, P; Picchio, M
File in questo prodotto:
File Dimensione Formato  
18F_FDG_PET_CT_May_Predict_Tumor_Type_and_Risk.8.pdf

Solo gestori archivio

Descrizione: Articolo
Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Dimensione 421.62 kB
Formato Adobe PDF
421.62 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/376976
Citazioni
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
Social impact