Purpose: The aim of this Intensive Care Medicine Rapid Practice Guideline (ICM‑RPG) was to formulate evidence‑based guidance for the use of dexmedetomidine for sedation in invasively mechanically ventilated adults in the intensive care unit (ICU). Methods: We adhered to the methodology for trustworthy clinical practice guidelines, including use of the Grading of Recommendations Assessment, Development, and Evaluation approach to assess the certainty of evidence, and the Evidence-to-Decision framework to generate recommendations. The guideline panel comprised 28 international panelists, including content experts, ICU clinicians, methodologists, and patient representatives. Through teleconferences and web‑based discussions, the panel provided input on the balance and magnitude of the desirable and undesirable effects, the certainty of evidence, patients’ values and preferences, costs and resources, feasibility, acceptability, and research priorities. Results: The ICM‑RPG panel issued one weak recommendation (suggestion) based on overall moderate certainty of evidence: "In invasively mechanically ventilated adult ICU patients, we suggest using dexmedetomidine over other sedative agents, if the desirable effects including a reduction in delirium are valued over the undesirable effects including an increase in hypotension and bradycardia". Conclusion: This ICM-RPG provides updated evidence-based guidance on the use of dexmedetomidine for sedation in mechanically ventilated adults, and outlines uncertainties and research priorities.

Møller, M., Alhazzani, W., Lewis, K., Belley-Cote, E., Granholm, A., Centofanti, J., et al. (2022). Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline. INTENSIVE CARE MEDICINE [10.1007/s00134-022-06660-x].

Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline

Citerio, Giuseppe;
2022

Abstract

Purpose: The aim of this Intensive Care Medicine Rapid Practice Guideline (ICM‑RPG) was to formulate evidence‑based guidance for the use of dexmedetomidine for sedation in invasively mechanically ventilated adults in the intensive care unit (ICU). Methods: We adhered to the methodology for trustworthy clinical practice guidelines, including use of the Grading of Recommendations Assessment, Development, and Evaluation approach to assess the certainty of evidence, and the Evidence-to-Decision framework to generate recommendations. The guideline panel comprised 28 international panelists, including content experts, ICU clinicians, methodologists, and patient representatives. Through teleconferences and web‑based discussions, the panel provided input on the balance and magnitude of the desirable and undesirable effects, the certainty of evidence, patients’ values and preferences, costs and resources, feasibility, acceptability, and research priorities. Results: The ICM‑RPG panel issued one weak recommendation (suggestion) based on overall moderate certainty of evidence: "In invasively mechanically ventilated adult ICU patients, we suggest using dexmedetomidine over other sedative agents, if the desirable effects including a reduction in delirium are valued over the undesirable effects including an increase in hypotension and bradycardia". Conclusion: This ICM-RPG provides updated evidence-based guidance on the use of dexmedetomidine for sedation in mechanically ventilated adults, and outlines uncertainties and research priorities.
Articolo in rivista - Articolo scientifico
Scientifica
Clinical practice guideline; Dexmedetomidine; ICM-RPG; Sedation;
English
Møller, M., Alhazzani, W., Lewis, K., Belley-Cote, E., Granholm, A., Centofanti, J., et al. (2022). Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline. INTENSIVE CARE MEDICINE [10.1007/s00134-022-06660-x].
Møller, M; Alhazzani, W; Lewis, K; Belley-Cote, E; Granholm, A; Centofanti, J; Mcintyre, W; Spence, J; Al Duhailib, Z; Needham, D; Evans, L; Reintam Blaser, A; Pisani, M; D’Aragon, F; Shankar-Hari, M; Alshahrani, M; Citerio, G; Arora, R; Mehta, S; Girard, T; Ranzani, O; Hammond, N; Devlin, J; Shehabi, Y; Pandharipande, P; Ostermann, M
File in questo prodotto:
File Dimensione Formato  
Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients_a rapid practice guideline ICM 2022.pdf

Solo gestori archivio

Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Dimensione 1.42 MB
Formato Adobe PDF
1.42 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/376427
Citazioni
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
Social impact