In 40 out of 99 patients (40.4%) with solid tumours of different tissue, but the same stage (IV), elevated serum levels of interleukin-10 were observed. The mean levels of the cytokine in patients with malignant melanoma (24.3 ng/ml), pancreatic (6.8 ng/ml) or gastric (6.3 ng/ml) adenocarcinoma were significantly higher than in healthy subjects (3.4 ng/ml) or in patients with uterine fibroma (1.7 ng/ml). Patients with colon (6.8 ng/ml) and renal (5.7 ng/ml) carcinoma had similar values of interleukin-10 but did not significantly differ from controls. Interleukin-10 is known to suppress the functions of both T lymphocytes and macrophages, working as a general dampener of the immune and inflammatory responses. The observation of increased circulating levels of interleukin-10 in cancer patients may have important implications for future investigations, immunological monitoring and therapeutic intervention on neoplastic patients, and suggests a mechanism for tumour cells escaping from immune surveillance.

Fortis, C., Foppoli, M., Gianotti, L., Galli, L., Citterio, G., Consogno, G., et al. (1996). Increased interleukin-10 serum levels in patients with solid tumours. CANCER LETTERS, 104(1), 1-5 [10.1016/0304-3835(96)04213-9].

Increased interleukin-10 serum levels in patients with solid tumours

GIANOTTI, LUCA VITTORIO;Braga, M.
1996

Abstract

In 40 out of 99 patients (40.4%) with solid tumours of different tissue, but the same stage (IV), elevated serum levels of interleukin-10 were observed. The mean levels of the cytokine in patients with malignant melanoma (24.3 ng/ml), pancreatic (6.8 ng/ml) or gastric (6.3 ng/ml) adenocarcinoma were significantly higher than in healthy subjects (3.4 ng/ml) or in patients with uterine fibroma (1.7 ng/ml). Patients with colon (6.8 ng/ml) and renal (5.7 ng/ml) carcinoma had similar values of interleukin-10 but did not significantly differ from controls. Interleukin-10 is known to suppress the functions of both T lymphocytes and macrophages, working as a general dampener of the immune and inflammatory responses. The observation of increased circulating levels of interleukin-10 in cancer patients may have important implications for future investigations, immunological monitoring and therapeutic intervention on neoplastic patients, and suggests a mechanism for tumour cells escaping from immune surveillance.
Articolo in rivista - Articolo scientifico
Interleukin-10; Reference Values; Neoplasms; Neoplasm Staging; Humans; Adult; Aged; Middle Aged; Male; Female
English
1996
104
1
1
5
none
Fortis, C., Foppoli, M., Gianotti, L., Galli, L., Citterio, G., Consogno, G., et al. (1996). Increased interleukin-10 serum levels in patients with solid tumours. CANCER LETTERS, 104(1), 1-5 [10.1016/0304-3835(96)04213-9].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/37493
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