IntroductionThe role of sex compared to comorbidities and other prognostic variables in patients with coronavirus disease (COVID-19) is unclear.MethodsThis is a retrospective observational study on patients with COVID-19 infection, referred to 13 cardiology units. The primary objective was to assess the difference in risk of death between the sexes. The secondary objective was to explore sex-based heterogeneity in the association between demographic, clinical and laboratory variables, and patients' risk of death.ResultsSeven hundred and one patients were included: 214 (30.5%) women and 487 (69.5%) men. During a median follow-up of 15-days, deaths occurred in 39 (18.2%) women and 126 (25.9%) men. In a multivariable Cox regression model, men had a nonsignificantly higher risk of death vs. women (P = 0.07).The risk of death was more than double in men with a low lymphocytes count as compared with men with a high lymphocytes count [overall survival hazard ratio (OS-HR) 2.56, 95% confidence interval (CI) 1.72-3.81]. In contrast, lymphocytes count was not related to death in women (P=0.03).Platelets count was associated with better outcome in men (OS-HR for increase of 50-×-103units: 0.88 95% CI 0.78-1.00) but not in women. The strength of association between higher PaO2/FiO2ratio and lower risk of death was larger in women (OS-HR for increase of 50-mmHg/%: 0.72, 95% CI 0.59-0.89) vs. men (OS-HR: 0.88, 95% CI 0.80-0.98; P-=-0.05).ConclusionsPatients' sex is a relevant variable that should be taken into account when evaluating risk of death from COVID-19. There is a sex-based heterogeneity in the association between baseline variables and patients' risk of death.

Lombardi, C., Specchia, C., Conforti, F., Rovere, M., Carubelli, V., Agostoni, P., et al. (2022). Sex-related differences in patients with coronavirus disease 2019: Results of the Cardio-COVID-Italy multicentre study. JOURNAL OF CARDIOVASCULAR MEDICINE, 23(4), 254-263 [10.2459/JCM.0000000000001261].

Sex-related differences in patients with coronavirus disease 2019: Results of the Cardio-COVID-Italy multicentre study

Senni M.;
2022

Abstract

IntroductionThe role of sex compared to comorbidities and other prognostic variables in patients with coronavirus disease (COVID-19) is unclear.MethodsThis is a retrospective observational study on patients with COVID-19 infection, referred to 13 cardiology units. The primary objective was to assess the difference in risk of death between the sexes. The secondary objective was to explore sex-based heterogeneity in the association between demographic, clinical and laboratory variables, and patients' risk of death.ResultsSeven hundred and one patients were included: 214 (30.5%) women and 487 (69.5%) men. During a median follow-up of 15-days, deaths occurred in 39 (18.2%) women and 126 (25.9%) men. In a multivariable Cox regression model, men had a nonsignificantly higher risk of death vs. women (P = 0.07).The risk of death was more than double in men with a low lymphocytes count as compared with men with a high lymphocytes count [overall survival hazard ratio (OS-HR) 2.56, 95% confidence interval (CI) 1.72-3.81]. In contrast, lymphocytes count was not related to death in women (P=0.03).Platelets count was associated with better outcome in men (OS-HR for increase of 50-×-103units: 0.88 95% CI 0.78-1.00) but not in women. The strength of association between higher PaO2/FiO2ratio and lower risk of death was larger in women (OS-HR for increase of 50-mmHg/%: 0.72, 95% CI 0.59-0.89) vs. men (OS-HR: 0.88, 95% CI 0.80-0.98; P-=-0.05).ConclusionsPatients' sex is a relevant variable that should be taken into account when evaluating risk of death from COVID-19. There is a sex-based heterogeneity in the association between baseline variables and patients' risk of death.
Articolo in rivista - Articolo scientifico
coronavirus study; inflammation; outcome; sex differences;
English
254
263
10
Lombardi, C., Specchia, C., Conforti, F., Rovere, M., Carubelli, V., Agostoni, P., et al. (2022). Sex-related differences in patients with coronavirus disease 2019: Results of the Cardio-COVID-Italy multicentre study. JOURNAL OF CARDIOVASCULAR MEDICINE, 23(4), 254-263 [10.2459/JCM.0000000000001261].
Lombardi, C; Specchia, C; Conforti, F; Rovere, M; Carubelli, V; Agostoni, P; Carugo, S; Danzi, G; Guazzi, M; Mortara, A; Piepoli, M; Porto, I; Sinagra, G; Volterrani, M; Ameri, P; Gnecchi, M; Leonardi, S; Merlo, M; Iorio, A; Bellasi, A; Canale, C; Camporotondo, R; Catagnano, F; Dalla Vecchia, L; Di Pasquale, M; Giovinazzo, S; Maccagni, G; Mapelli, M; Margonato, D; Monzo, L; Nuzzi, V; Oriecuia, C; Pala, L; Peveri, G; Pozzi, A; Provenzale, G; Sarullo, F; Adamo, M; Tomasoni, D; Inciardi, R; Senni, M; Metra, M
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/373455
Citazioni
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
Social impact