This critical review illustrates the pathophysiological aspects and available scientific evidence about cardiac contractility modulation therapy. A useful algorithm dealing with the essential decisional knots to consider for device implantation in patients with heart failure in NYHA class >II and ejection fraction <= 45% is presented. The present review paves the way for the development of an Italian registry aiming at analyzing the characteristics of implanted patients based on a multiparametric approach, including cardiac bio markers, to identify clinical profiles and predictors of response to therapy. The "Answers and Questions" section provides useful insights into pathophysiology, technical specifications, clinically relevant scenarios and future perspectives.

Biffi, M., Aspromonte, N., Bongiorni, M., Clemenza, F., D'Onofrio, A., De Ferrari, G., et al. (2021). Cardiac contractility modulation in heart failure with reduced ejection fraction: critical review of evidence and application perspectives [Modulazione della contrattilità cardiaca nello scompenso cardiaco a frazione di eiezione ridotta: revisione critica delle evidenze ed aspetti decisionali pratici]. GIORNALE ITALIANO DI CARDIOLOGIA, 22(9), 727-741 [10.1714/3660.36450].

Cardiac contractility modulation in heart failure with reduced ejection fraction: critical review of evidence and application perspectives [Modulazione della contrattilità cardiaca nello scompenso cardiaco a frazione di eiezione ridotta: revisione critica delle evidenze ed aspetti decisionali pratici]

Senni M;
2021

Abstract

This critical review illustrates the pathophysiological aspects and available scientific evidence about cardiac contractility modulation therapy. A useful algorithm dealing with the essential decisional knots to consider for device implantation in patients with heart failure in NYHA class >II and ejection fraction <= 45% is presented. The present review paves the way for the development of an Italian registry aiming at analyzing the characteristics of implanted patients based on a multiparametric approach, including cardiac bio markers, to identify clinical profiles and predictors of response to therapy. The "Answers and Questions" section provides useful insights into pathophysiology, technical specifications, clinically relevant scenarios and future perspectives.
Articolo in rivista - Review Essay
Heart Failure; Humans; Myocardial Contraction; Registries; Stroke Volume; Treatment Outcome;
Italian
727
741
15
Biffi, M., Aspromonte, N., Bongiorni, M., Clemenza, F., D'Onofrio, A., De Ferrari, G., et al. (2021). Cardiac contractility modulation in heart failure with reduced ejection fraction: critical review of evidence and application perspectives [Modulazione della contrattilità cardiaca nello scompenso cardiaco a frazione di eiezione ridotta: revisione critica delle evidenze ed aspetti decisionali pratici]. GIORNALE ITALIANO DI CARDIOLOGIA, 22(9), 727-741 [10.1714/3660.36450].
Biffi, M; Aspromonte, N; Bongiorni, M; Clemenza, F; D'Onofrio, A; De Ferrari, G; Giallauria, F; Grimaldi, M; Oliva, F; Senni, M; Tondo, C; Zecchin, M; Cappannoli, L; Giannotti Santoro, M; Ziacchi, M; Porcari, A; Sinagra, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/373411
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