Acute heart failure (HF) is a global pandemic with more than one million admissions to hospital annually in the US and millions more worldwide. Post-discharge mortality and readmission rates remain unchanged and unacceptably high. Although recent drug development programmes have failed to deliver novel therapies capable of reducing cardiovascular morbidity and mortality in patients hospitalized for worsening chronic HF, hospitalized HF registries and clinical trial databases have generated a wealth of information improving our collective understanding of the HF syndrome. This review will summarize key insights from clinical trials in acute HF and hospitalized HF registries over the last several decades, focusing on improving the management of patients with HF and reduced ejection fraction.

Cheema, B., Ambrosy, A., Kaplan, R., Senni, M., Fonarow, G., Chioncel, O., et al. (2018). Lessons learned in acute heart failure. EUROPEAN JOURNAL OF HEART FAILURE, 20(4), 630-641 [10.1002/ejhf.1042].

Lessons learned in acute heart failure

Senni M;
2018

Abstract

Acute heart failure (HF) is a global pandemic with more than one million admissions to hospital annually in the US and millions more worldwide. Post-discharge mortality and readmission rates remain unchanged and unacceptably high. Although recent drug development programmes have failed to deliver novel therapies capable of reducing cardiovascular morbidity and mortality in patients hospitalized for worsening chronic HF, hospitalized HF registries and clinical trial databases have generated a wealth of information improving our collective understanding of the HF syndrome. This review will summarize key insights from clinical trials in acute HF and hospitalized HF registries over the last several decades, focusing on improving the management of patients with HF and reduced ejection fraction.
Articolo in rivista - Articolo scientifico
Acute heart failure; Clinical trial; Registry;
English
630
641
12
Cheema, B., Ambrosy, A., Kaplan, R., Senni, M., Fonarow, G., Chioncel, O., et al. (2018). Lessons learned in acute heart failure. EUROPEAN JOURNAL OF HEART FAILURE, 20(4), 630-641 [10.1002/ejhf.1042].
Cheema, B; Ambrosy, A; Kaplan, R; Senni, M; Fonarow, G; Chioncel, O; Butler, J; Gheorghiade, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/372684
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