BACKGROUND: In the recent Italian Network on Heart Failure (IN-HF) Outcome registry, including 1,855 patients with acute heart failure (AHF), were viewed the use of inotropes and their prognostic implication onin-hospital and 12-month mortality. METHODS: IN-HF Outcome is aprospective, multicenter, observational, study involving 61 Italian cardiology centers. AHF patients have been enrolled over a 2-year period and followed-up for 1 year. Inotropes were used in 360 patients (19.4%). RESULTS: Patients who received inotropes had a more severe clinical and hemodynamic profile than those who did not and exhibited a significantly higher rate of in-hospital (21.4% vs 2.7%, p < 0.01) and 1-year (50.6% vs 17.7%, p < 0.01) mortality. At entry, systolic blood pressure (SBP) was < 110 mm Hg in 58%, 111 to 130 mm Hg in 24.5%, and > 130 mm Hg in 17.5%. Multivariable analyses showed use of inotropes was the strongest predictor of all-cause death. These data were confirmed by propensity score analyses. According to SBP at entry, the 2 groups with SBP > 110 mm Hg who took inotropes, despite a more favorable clinical profile, exhibited a similar worse prognosis, particularly at 1 year: 56.3% (≤ 110 mmHg), 43.7% (111-130 mm Hg), and 40.3% (4130 mm Hg) vs 17.7%. CONCLUSIONS: Inotropes were used in nearly 20% of the patient admitted for AHF, and this treatment was associated with a short-term to medium-term poor prognosis. An inappropriate use of inotropes in patients with normal to high SBP, and presumably preserved cardiac output, may have significantly contributed to affect the all-group outcome.

Mortara, A., Oliva, F., Metra, M., Carbonieri, E., Di Lenarda, A., Gorini, M., et al. (2014). Treatment with inotropes and related prognosis in acute heart failure: Contemporary data from the Italian Network on Heart Failure (IN-HF) Outcome registry. THE JOURNAL OF HEART AND LUNG TRANSPLANTATION, 33(10), 1056-1065 [10.1016/j.healun.2014.05.015].

Treatment with inotropes and related prognosis in acute heart failure: Contemporary data from the Italian Network on Heart Failure (IN-HF) Outcome registry

Senni M;
2014

Abstract

BACKGROUND: In the recent Italian Network on Heart Failure (IN-HF) Outcome registry, including 1,855 patients with acute heart failure (AHF), were viewed the use of inotropes and their prognostic implication onin-hospital and 12-month mortality. METHODS: IN-HF Outcome is aprospective, multicenter, observational, study involving 61 Italian cardiology centers. AHF patients have been enrolled over a 2-year period and followed-up for 1 year. Inotropes were used in 360 patients (19.4%). RESULTS: Patients who received inotropes had a more severe clinical and hemodynamic profile than those who did not and exhibited a significantly higher rate of in-hospital (21.4% vs 2.7%, p < 0.01) and 1-year (50.6% vs 17.7%, p < 0.01) mortality. At entry, systolic blood pressure (SBP) was < 110 mm Hg in 58%, 111 to 130 mm Hg in 24.5%, and > 130 mm Hg in 17.5%. Multivariable analyses showed use of inotropes was the strongest predictor of all-cause death. These data were confirmed by propensity score analyses. According to SBP at entry, the 2 groups with SBP > 110 mm Hg who took inotropes, despite a more favorable clinical profile, exhibited a similar worse prognosis, particularly at 1 year: 56.3% (≤ 110 mmHg), 43.7% (111-130 mm Hg), and 40.3% (4130 mm Hg) vs 17.7%. CONCLUSIONS: Inotropes were used in nearly 20% of the patient admitted for AHF, and this treatment was associated with a short-term to medium-term poor prognosis. An inappropriate use of inotropes in patients with normal to high SBP, and presumably preserved cardiac output, may have significantly contributed to affect the all-group outcome.
Articolo in rivista - Articolo scientifico
acute heart; blood; death prognosis; failure; IN-HF; inotropes systolic; Outcome registry; pressure;
English
1056
1065
10
Mortara, A., Oliva, F., Metra, M., Carbonieri, E., Di Lenarda, A., Gorini, M., et al. (2014). Treatment with inotropes and related prognosis in acute heart failure: Contemporary data from the Italian Network on Heart Failure (IN-HF) Outcome registry. THE JOURNAL OF HEART AND LUNG TRANSPLANTATION, 33(10), 1056-1065 [10.1016/j.healun.2014.05.015].
Mortara, A; Oliva, F; Metra, M; Carbonieri, E; Di Lenarda, A; Gorini, M; Midi, P; Senni, M; Urso, R; Lucci, D; Maggioni, A; Tavazzi, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/372080
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