he review aims to discuss the role of nerve growth factor (NGF) as a potential novel biomarker in post-myocardial infarction (MI) and in heart failure (HF), with a specific focus on neural remodeling and sprouting processes occurring after tissue damage. Many experimental data show that MI induces nerve sprouting, leading to increased sympathetic outflow and higher risk of ventricular arrhythmias and sudden cardiac death. In this framework, cardiac and circulating NGF might be an indicator of the innervation process and neural remodeling: it dramatically increases after MI, while it declines along with advanced HF and ventricular dysfunction. The bimodal behavior of NGF in acute and chronic settings leads to the speculation that NGF modulation may be a pharmacological target for intervention in different stages of the ischemic heart disease. Specifically, a fascinating possibility is to support or to inhibit NGF receptors, in order to prevent negative cardiac remodeling after MI and consequent ventricular dysfunction.

D'Elia, E., Pascale, A., Marchesi, N., Ferrero, P., Senni, M., Govoni, S., et al. (2014). Novel approaches to the post-myocardial infarction/heart failure neural remodeling. HEART FAILURE REVIEWS, 19(5), 611-619 [10.1007/s10741-013-9415-6].

Novel approaches to the post-myocardial infarction/heart failure neural remodeling

Senni M;
2014

Abstract

he review aims to discuss the role of nerve growth factor (NGF) as a potential novel biomarker in post-myocardial infarction (MI) and in heart failure (HF), with a specific focus on neural remodeling and sprouting processes occurring after tissue damage. Many experimental data show that MI induces nerve sprouting, leading to increased sympathetic outflow and higher risk of ventricular arrhythmias and sudden cardiac death. In this framework, cardiac and circulating NGF might be an indicator of the innervation process and neural remodeling: it dramatically increases after MI, while it declines along with advanced HF and ventricular dysfunction. The bimodal behavior of NGF in acute and chronic settings leads to the speculation that NGF modulation may be a pharmacological target for intervention in different stages of the ischemic heart disease. Specifically, a fascinating possibility is to support or to inhibit NGF receptors, in order to prevent negative cardiac remodeling after MI and consequent ventricular dysfunction.
Articolo in rivista - Articolo scientifico
Autonomic nervous system; Heart failure; Nerve sprouting; Neural remodeling;
English
611
619
9
D'Elia, E., Pascale, A., Marchesi, N., Ferrero, P., Senni, M., Govoni, S., et al. (2014). Novel approaches to the post-myocardial infarction/heart failure neural remodeling. HEART FAILURE REVIEWS, 19(5), 611-619 [10.1007/s10741-013-9415-6].
D'Elia, E; Pascale, A; Marchesi, N; Ferrero, P; Senni, M; Govoni, S; Gronda, E; Vanoli, E
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/372071
Citazioni
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 7
Social impact