In recent years several synthetic peptides have been shown to be active in inducing GH secretion in different mammalian species. Among them GHRP-6, GHRP-1 and GHRP-2 have demonstrated high effectiveness and high selectivity in stimulating GH release. In the present paper we report studies on the GH-secreting properties of a GHRP analog in which Trp was substituted with the chemically more stable 2-Methyl-Trp. In studies performed in conscious 10-day old rats, the hexapeptide Hexarelin (His-D-2Me-Trp-Ala-Trp-D-Phe-Lys-NH2) resulted very active in stimulating GH secretion. In anesthetized adult male rats, i.v. administration of GHRP-6 or Hexarelin elicited prompt GH release with peak GH levels occurring within 10 min At all the doses tested, the 2 peptides possessed similar effectiveness in stimulating GH release. Hexarelin given s.c. elicited a long-lasting GH release and was slightly more effective than GHRP-6. In conclusion, these findings indicate that Hexarelin is a highly effective GH releaser and might represent a valuable diagnostic and/or therapeutic tool in clinical practice.

Deghenghi, R., Cananzi, M., Torsello, A., Battisti, C., Muller, E., & Locatelli, V. (1994). GH-releasing activity of Hexarelin, a new growth hormone releasing peptide, in infant and adult rats. LIFE SCIENCES, 54(18), 1321-1328 [10.1016/0024-3205(94)00510-9].

GH-releasing activity of Hexarelin, a new growth hormone releasing peptide, in infant and adult rats

TORSELLO, ANTONIO BIAGIO;LOCATELLI, VITTORIO
1994

Abstract

In recent years several synthetic peptides have been shown to be active in inducing GH secretion in different mammalian species. Among them GHRP-6, GHRP-1 and GHRP-2 have demonstrated high effectiveness and high selectivity in stimulating GH release. In the present paper we report studies on the GH-secreting properties of a GHRP analog in which Trp was substituted with the chemically more stable 2-Methyl-Trp. In studies performed in conscious 10-day old rats, the hexapeptide Hexarelin (His-D-2Me-Trp-Ala-Trp-D-Phe-Lys-NH2) resulted very active in stimulating GH secretion. In anesthetized adult male rats, i.v. administration of GHRP-6 or Hexarelin elicited prompt GH release with peak GH levels occurring within 10 min At all the doses tested, the 2 peptides possessed similar effectiveness in stimulating GH release. Hexarelin given s.c. elicited a long-lasting GH release and was slightly more effective than GHRP-6. In conclusion, these findings indicate that Hexarelin is a highly effective GH releaser and might represent a valuable diagnostic and/or therapeutic tool in clinical practice.
Articolo in rivista - Articolo scientifico
Scientifica
Animals; Dose-Response Relationship, Drug; Growth Substances; Aging; Amino Acid Sequence; Somatostatin; Structure-Activity Relationship; Rats; Molecular Sequence Data; Growth Hormone-Releasing Hormone; Oligopeptides; Female; Male
English
Deghenghi, R., Cananzi, M., Torsello, A., Battisti, C., Muller, E., & Locatelli, V. (1994). GH-releasing activity of Hexarelin, a new growth hormone releasing peptide, in infant and adult rats. LIFE SCIENCES, 54(18), 1321-1328 [10.1016/0024-3205(94)00510-9].
Deghenghi, R; Cananzi, M; Torsello, A; Battisti, C; Muller, E; Locatelli, V
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/37152
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