Insulin resistance characterizes type I diabetes in patients with albuminuria. A PC-1 glycoprotein amino acid variant, K121Q, is associated with insulin resistance. We examined the impact of the PC-1 K121Q variant on the rate of decline of the glomerular filtration rate (GFR) by creatinine clearance derived from the Cockroft-Gault formula in 77 type I diabetic patients with albuminuria who were followed for an average of 6.5 years (range 2.5-15). Patients carrying the Q allele (n = 22; 20 with KQ and 2 with QQ genotypes) had a faster GFR decline than those patients with the KK genotype (n = 55) (median 7.2 vs. 3.7 ml · min-1 · year-1; range 0.16 to 16.6 vs. -3.8 to 16.0 ml · min-1 · year-1; P< 0.001). Significantly more patients carrying the Q allele belonged to the highest tertile of GFR decline (odds ratio = 5.7, 95% CI 4.1-7.2, P = 0.02). Levels of blood pressure, HbA(1c), and albuminuria were comparable in the two genotype groups. Albuminuria (P = 0.001), mean blood pressure (P = 0.046), and PC-1 genotype (P = 0.036) independently correlated with GFR decline. Because all patients were receiving antihypertensive treatment, the faster GFR decline in the patients carrying the Q allele could be the result of reduced sensitivity to the renoprotective effect of antihypertensive therapy. PC-1 genotyping identifies type I diabetic patients with a faster progression of diabetic nephropathy.

De Cosmo, S., Argiolas, A., Miscio, G., Thomas, S., Piras, G., Trevisan, R., et al. (2000). A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuria. DIABETES, 49(3), 521-524 [10.2337/diabetes.49.3.521].

A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuria

Trevisan R;
2000

Abstract

Insulin resistance characterizes type I diabetes in patients with albuminuria. A PC-1 glycoprotein amino acid variant, K121Q, is associated with insulin resistance. We examined the impact of the PC-1 K121Q variant on the rate of decline of the glomerular filtration rate (GFR) by creatinine clearance derived from the Cockroft-Gault formula in 77 type I diabetic patients with albuminuria who were followed for an average of 6.5 years (range 2.5-15). Patients carrying the Q allele (n = 22; 20 with KQ and 2 with QQ genotypes) had a faster GFR decline than those patients with the KK genotype (n = 55) (median 7.2 vs. 3.7 ml · min-1 · year-1; range 0.16 to 16.6 vs. -3.8 to 16.0 ml · min-1 · year-1; P< 0.001). Significantly more patients carrying the Q allele belonged to the highest tertile of GFR decline (odds ratio = 5.7, 95% CI 4.1-7.2, P = 0.02). Levels of blood pressure, HbA(1c), and albuminuria were comparable in the two genotype groups. Albuminuria (P = 0.001), mean blood pressure (P = 0.046), and PC-1 genotype (P = 0.036) independently correlated with GFR decline. Because all patients were receiving antihypertensive treatment, the faster GFR decline in the patients carrying the Q allele could be the result of reduced sensitivity to the renoprotective effect of antihypertensive therapy. PC-1 genotyping identifies type I diabetic patients with a faster progression of diabetic nephropathy.
Articolo in rivista - Articolo scientifico
Insulin resistance, type 1 diabetes, albuminuria, PC-1 K121Q variant;
English
2000
49
3
521
524
reserved
De Cosmo, S., Argiolas, A., Miscio, G., Thomas, S., Piras, G., Trevisan, R., et al. (2000). A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuria. DIABETES, 49(3), 521-524 [10.2337/diabetes.49.3.521].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/368329
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