Objective: To define similarities and differences between neonatal arterial ischemic stroke (NAIS) and hypoxic-ischemic neonatal encephalopathy (HINE). Methods: A retrospective case-control study was conducted of neonates born at 35 weeks or more and weighing 1800 g or more at a tertiary care university hospital, between 2005 and 2016, with NAIS (group A), perinatal asphyxia (PA) with Stage II–III HINE (group B), and PA with or without Stage I HINE (group C). Ante- and intrapartum data, neonatal characteristics, and placental histopathology were compared. Results: Eleven neonates were identified in group A, 10 in group B, and 227 in group C. Sentinel events occurred exclusively in groups B (80%) and C (41.4%). Umbilical cord blood gas values and Apgar score were worse in groups B and C compared to group A. No group A neonates required resuscitation at birth, whereas all group B and one-third of group C neonates did. Seizures developed only in neonates in groups A and B. One neonatal death occurred in group A. There were no significant differences in placental histopathology. Conclusion: NAIS and PA/HINE cases have different intrapartum and neonatal features. PA does not seem necessary for the occurrence of NAIS. More research is needed regarding associated placental abnormalities.

Lambicchi, L., Ornaghi, S., Dal Molin, G., Paterlini, G., Bernasconi, D., Moltrasio, F., et al. (2021). Different antecedents and neonatal condition in neonatal arterial ischemic stroke and hypoxic-ischemic neonatal encephalopathy. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS [10.1002/ijgo.13781].

Different antecedents and neonatal condition in neonatal arterial ischemic stroke and hypoxic-ischemic neonatal encephalopathy

Lambicchi L.;Ornaghi S.;Paterlini G.;Bernasconi D. P.;Moltrasio F.;Vergani P.
2021

Abstract

Objective: To define similarities and differences between neonatal arterial ischemic stroke (NAIS) and hypoxic-ischemic neonatal encephalopathy (HINE). Methods: A retrospective case-control study was conducted of neonates born at 35 weeks or more and weighing 1800 g or more at a tertiary care university hospital, between 2005 and 2016, with NAIS (group A), perinatal asphyxia (PA) with Stage II–III HINE (group B), and PA with or without Stage I HINE (group C). Ante- and intrapartum data, neonatal characteristics, and placental histopathology were compared. Results: Eleven neonates were identified in group A, 10 in group B, and 227 in group C. Sentinel events occurred exclusively in groups B (80%) and C (41.4%). Umbilical cord blood gas values and Apgar score were worse in groups B and C compared to group A. No group A neonates required resuscitation at birth, whereas all group B and one-third of group C neonates did. Seizures developed only in neonates in groups A and B. One neonatal death occurred in group A. There were no significant differences in placental histopathology. Conclusion: NAIS and PA/HINE cases have different intrapartum and neonatal features. PA does not seem necessary for the occurrence of NAIS. More research is needed regarding associated placental abnormalities.
Articolo in rivista - Articolo scientifico
encephalopathy; hypoxic-ischemic neonatal; neonatal arterial ischemic stroke; neonatal seizures; perinatal asphyxia; placental histology; sentinel events; umbilical artery pH;
English
Lambicchi, L., Ornaghi, S., Dal Molin, G., Paterlini, G., Bernasconi, D., Moltrasio, F., et al. (2021). Different antecedents and neonatal condition in neonatal arterial ischemic stroke and hypoxic-ischemic neonatal encephalopathy. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS [10.1002/ijgo.13781].
Lambicchi, L; Ornaghi, S; Dal Molin, G; Paterlini, G; Bernasconi, D; Moltrasio, F; Vergani, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/363890
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