Intrinsically bursting (IB) neurons, responding with a burst of action potentials to just threshold intracellular depolarizing current pulses, are encountered in layer V of mature rodent sensorimotor cortex. We report the results of intracellular recordings performed on neocortical slices obtained from immature rats between postnatal day (P) 7 and P21, as compared to adult animals (above P60). The bursting properties are here reported to mature abruptly around P14. After this time a subpopulation of IB neurons was recognizable on the basis of both physiological and morphological characteristics (i.e. extensive apical and basal dendrites arborization, axon collaterals limited to layers V-VI). Maturational changes in number and distribution of Ca2+/K+ channels may account for this developmental step. The immaturity of IB neurons may be correlated with the poorly synchronized character of cortical activities in the very young animals.

Franceschetti, S., Buzio, S., Sancini, G., Panzica, F., & Avanzini, G. (1993). Expression of intrinsic bursting properties in neurons of maturing sensorimotor cortex. NEUROSCIENCE LETTERS, 162(1-2), 25-28.

Expression of intrinsic bursting properties in neurons of maturing sensorimotor cortex

SANCINI, GIULIO ALFREDO;
1993-11-12

Abstract

Intrinsically bursting (IB) neurons, responding with a burst of action potentials to just threshold intracellular depolarizing current pulses, are encountered in layer V of mature rodent sensorimotor cortex. We report the results of intracellular recordings performed on neocortical slices obtained from immature rats between postnatal day (P) 7 and P21, as compared to adult animals (above P60). The bursting properties are here reported to mature abruptly around P14. After this time a subpopulation of IB neurons was recognizable on the basis of both physiological and morphological characteristics (i.e. extensive apical and basal dendrites arborization, axon collaterals limited to layers V-VI). Maturational changes in number and distribution of Ca2+/K+ channels may account for this developmental step. The immaturity of IB neurons may be correlated with the poorly synchronized character of cortical activities in the very young animals.
Articolo in rivista - Articolo scientifico
Scientifica
Kinetics; Motor Cortex; Tetrodotoxin; Action Potentials; Neurons; Rats, Wistar; Rats; Animals; Pyramidal Cells; Lysine; Somatosensory Cortex; Tetraethylammonium Compounds
English
Franceschetti, S., Buzio, S., Sancini, G., Panzica, F., & Avanzini, G. (1993). Expression of intrinsic bursting properties in neurons of maturing sensorimotor cortex. NEUROSCIENCE LETTERS, 162(1-2), 25-28.
Franceschetti, S; Buzio, S; Sancini, G; Panzica, F; Avanzini, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/36312
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