Genetic absence epilepsy rats from Strasbourg (GAERS) have non-convulsive generalized seizures associated with spike-wave (SW) discharges, which are due to a hyperexcitable state of the thalamo-cortico circuits involving the reticular thalamic nucleus (nRt). Investigation of the primary genetically-determined defect responsible for GAERS epilepsy revealed the following abnormalities: (1) increased effectiveness of AMPA receptors dependent glutamate-mediated transmission; (2) impairment of GABA-mediated transmission in the neocortex; (3) increased amplitude of the voltage-dependent low-threshold Ca2(+)-current (I(T)) in the nRt. The maturational profile of these abnormalities supports the conclusion that the abnormality in the I(T) current in the nRt is the primary genetically-determined defect, which may secondarily induce the other changes found in the neocortex and thalamus of GAERS.

Avanzini, G., de Curtis, M., Franceschetti, S., Sancini, G., & Spreafico, R. (1996). Cortical versus thalamic mechanisms underlying spike and wave discharges in GAERS. EPILEPSY RESEARCH, 26(1), 37-44 [10.1016/S0920-1211(96)00037-X].

Cortical versus thalamic mechanisms underlying spike and wave discharges in GAERS

SANCINI, GIULIO ALFREDO;
1996

Abstract

Genetic absence epilepsy rats from Strasbourg (GAERS) have non-convulsive generalized seizures associated with spike-wave (SW) discharges, which are due to a hyperexcitable state of the thalamo-cortico circuits involving the reticular thalamic nucleus (nRt). Investigation of the primary genetically-determined defect responsible for GAERS epilepsy revealed the following abnormalities: (1) increased effectiveness of AMPA receptors dependent glutamate-mediated transmission; (2) impairment of GABA-mediated transmission in the neocortex; (3) increased amplitude of the voltage-dependent low-threshold Ca2(+)-current (I(T)) in the nRt. The maturational profile of these abnormalities supports the conclusion that the abnormality in the I(T) current in the nRt is the primary genetically-determined defect, which may secondarily induce the other changes found in the neocortex and thalamus of GAERS.
Articolo in rivista - Articolo scientifico
Thalamic Nuclei; Rats; Animals; 2-Amino-5-phosphonovalerate; Receptors, N-Methyl-D-Aspartate; Cerebral Cortex; Electric Stimulation; Disease Models, Animal; Epilepsy, Absence; Thalamus; Neural Pathways; Pyramidal Cells; gamma-Aminobutyric Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Synaptic Transmission
English
37
44
8
Avanzini, G., de Curtis, M., Franceschetti, S., Sancini, G., & Spreafico, R. (1996). Cortical versus thalamic mechanisms underlying spike and wave discharges in GAERS. EPILEPSY RESEARCH, 26(1), 37-44 [10.1016/S0920-1211(96)00037-X].
Avanzini, G; de Curtis, M; Franceschetti, S; Sancini, G; Spreafico, R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/36294
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