The murine homeobox-containing Otx gene is required for correct nervous system and sense organ development. Otx1-/1 mice obtained by replacing Otx with the lac Z gene show developmental abnormalities of the cerebellum, mesencephalon, and cerebral cortex associated with spontaneous epileptic seizures (1). The epileptogenic mechanisms accounting for these seizures were investigated by means of electrophysiological recordings made from neocortical slices.

Avanzini, G., Spreafico, R., Cipelletti, B., Sancini, G., Frassoni, C., Franceschetti, S., et al. (2000). Synaptic properties of neocortical neurons in epileptic mice lacking the Otx1 gene. EPILEPSIA, 41 Suppl 6, 200-205.

Synaptic properties of neocortical neurons in epileptic mice lacking the Otx1 gene

SANCINI, GIULIO ALFREDO;
2000

Abstract

The murine homeobox-containing Otx gene is required for correct nervous system and sense organ development. Otx1-/1 mice obtained by replacing Otx with the lac Z gene show developmental abnormalities of the cerebellum, mesencephalon, and cerebral cortex associated with spontaneous epileptic seizures (1). The epileptogenic mechanisms accounting for these seizures were investigated by means of electrophysiological recordings made from neocortical slices.
Articolo in rivista - Articolo scientifico
Scientifica
Mice, Neurologic Mutants; Otx Transcription Factors; Genes, Homeobox; Animals; Electric Stimulation; Neocortex; Patch-Clamp Techniques; Excitatory Postsynaptic Potentials; Mice; beta-Galactosidase; Homeodomain Proteins; Transcription Factors; Nerve Tissue Proteins; Epilepsy; Pyramidal Cells; Somatosensory Cortex; Synaptic Transmission
English
Avanzini, G., Spreafico, R., Cipelletti, B., Sancini, G., Frassoni, C., Franceschetti, S., et al. (2000). Synaptic properties of neocortical neurons in epileptic mice lacking the Otx1 gene. EPILEPSIA, 41 Suppl 6, 200-205.
Avanzini, G; Spreafico, R; Cipelletti, B; Sancini, G; Frassoni, C; Franceschetti, S; Lavazza, T; Panzica, F; Acampora, D; Simeone, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/36289
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