Background: The prevalence of atrial fibrillation is increased in patients with end-stage renal disease. Previous studies suggested that extracellular electrolyte alterations caused by hemodialysis (HD) therapy could be proarrhythmic. Methods: Multiscale models were used for a consequent analysis of the effects of extracellular ion concentration changes on atrial electrophysiology. Simulations were based on measured electrolyte concentrations from patients with end-stage renal disease. Results: Simulated conduction velocity and effective refractory period are decreased at the end of an HD session, with potassium having the strongest influence. P-wave is prolonged in patients undergoing HD therapy in the simulation as in measurements. Conclusions: Electrolyte concentration alterations impact atrial electrophysiology from the action potential level to the P-wave and can be proarrhythmic, especially because of induced hypokalemia. Analysis of blood electrolytes enables patient-specific electrophysiology modeling. We are providing a tool to investigate atrial arrhythmias associated with HD therapy, which, in the future, can be used to prevent such complications. © 2011 Elsevier Inc. All rights reserved.

Krueger, M., Severi, S., Rhode, K., Genovesi, S., Weber, F., Vincenti, A., et al. (2011). Alterations of atrial electrophysiology related to hemodialysis session: insights from a multiscale computer model. JOURNAL OF ELECTROCARDIOLOGY, 44(2), 176-183 [10.1016/j.jelectrocard.2010.11.016].

Alterations of atrial electrophysiology related to hemodialysis session: insights from a multiscale computer model

GENOVESI, SIMONETTA CARLA;
2011

Abstract

Background: The prevalence of atrial fibrillation is increased in patients with end-stage renal disease. Previous studies suggested that extracellular electrolyte alterations caused by hemodialysis (HD) therapy could be proarrhythmic. Methods: Multiscale models were used for a consequent analysis of the effects of extracellular ion concentration changes on atrial electrophysiology. Simulations were based on measured electrolyte concentrations from patients with end-stage renal disease. Results: Simulated conduction velocity and effective refractory period are decreased at the end of an HD session, with potassium having the strongest influence. P-wave is prolonged in patients undergoing HD therapy in the simulation as in measurements. Conclusions: Electrolyte concentration alterations impact atrial electrophysiology from the action potential level to the P-wave and can be proarrhythmic, especially because of induced hypokalemia. Analysis of blood electrolytes enables patient-specific electrophysiology modeling. We are providing a tool to investigate atrial arrhythmias associated with HD therapy, which, in the future, can be used to prevent such complications. © 2011 Elsevier Inc. All rights reserved.
Articolo in rivista - Articolo scientifico
Heart Conduction System; Models, Cardiovascular; Animals; Computer Simulation; Humans; Water-Electrolyte Imbalance; Renal Dialysis; Atrial Fibrillation; Water-Electrolyte Balance; Heart Atria
English
2011
44
2
176
183
none
Krueger, M., Severi, S., Rhode, K., Genovesi, S., Weber, F., Vincenti, A., et al. (2011). Alterations of atrial electrophysiology related to hemodialysis session: insights from a multiscale computer model. JOURNAL OF ELECTROCARDIOLOGY, 44(2), 176-183 [10.1016/j.jelectrocard.2010.11.016].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/36243
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