2-Amino-1,5-dihydro-1-[methyl-2H3] 4H-imidazol-4-one ([methyl-2H3] creatinine) was obtained by acidification and heating (120 °C, 120 min) of the [methyl -2H3] N-amidinosarcosine (creatine) synthesised by methylation of guanidoacetate (GA) with S-adenosyl-[methyl-2H3] L-methionine ([methyl-2H3] AdoMet) in the presence of rat liver guanidoacetate methyltransferase (GAA-MT). Isotopic enrichment was 94.7%.
Arcelloni, C., Paroni, R., Bonini, P., Magni, F., Kienle, M. (1992). Enzymatic synthesis of [methyl-2H3] creatinine. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 31(7), 505-517 [10.1002/jlcr.2580310703].
Enzymatic synthesis of [methyl-2H3] creatinine
MAGNI, FULVIO;
1992
Abstract
2-Amino-1,5-dihydro-1-[methyl-2H3] 4H-imidazol-4-one ([methyl-2H3] creatinine) was obtained by acidification and heating (120 °C, 120 min) of the [methyl -2H3] N-amidinosarcosine (creatine) synthesised by methylation of guanidoacetate (GA) with S-adenosyl-[methyl-2H3] L-methionine ([methyl-2H3] AdoMet) in the presence of rat liver guanidoacetate methyltransferase (GAA-MT). Isotopic enrichment was 94.7%.
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