2-Amino-1,5-dihydro-1-[methyl-2H3] 4H-imidazol-4-one ([methyl-2H3] creatinine) was obtained by acidification and heating (120 °C, 120 min) of the [methyl -2H3] N-amidinosarcosine (creatine) synthesised by methylation of guanidoacetate (GA) with S-adenosyl-[methyl-2H3] L-methionine ([methyl-2H3] AdoMet) in the presence of rat liver guanidoacetate methyltransferase (GAA-MT). Isotopic enrichment was 94.7%.

Arcelloni, C., Paroni, R., Bonini, P., Magni, F., Kienle, M. (1992). Enzymatic synthesis of [methyl-2H3] creatinine. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 31(7), 505-517 [10.1002/jlcr.2580310703].

Enzymatic synthesis of [methyl-2H3] creatinine

MAGNI, FULVIO;
1992

Abstract

2-Amino-1,5-dihydro-1-[methyl-2H3] 4H-imidazol-4-one ([methyl-2H3] creatinine) was obtained by acidification and heating (120 °C, 120 min) of the [methyl -2H3] N-amidinosarcosine (creatine) synthesised by methylation of guanidoacetate (GA) with S-adenosyl-[methyl-2H3] L-methionine ([methyl-2H3] AdoMet) in the presence of rat liver guanidoacetate methyltransferase (GAA-MT). Isotopic enrichment was 94.7%.
Articolo in rivista - Articolo scientifico
[methyl-2H3] creatinine; guanidoacetate methyltransferase; S-adenosyl-[methyl-2H3] L-methionine; isotope dilution - mass spectrometry
English
505
517
13
Arcelloni, C., Paroni, R., Bonini, P., Magni, F., Kienle, M. (1992). Enzymatic synthesis of [methyl-2H3] creatinine. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 31(7), 505-517 [10.1002/jlcr.2580310703].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/36191
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