BN-52021 preserves "in vitro" the actively sensitized guinea-pig heart from the immunological reaction. This ginkgolide reduces mediator release (histamine, thromboxane-A2 and slow reacting substance of anaphylaxis) in a dose-dependent manner, particularly that of histamine. These results evidence either an important role for PAF in guinea pig anaphylaxis or a wider spectrum of activity for BN-52021.
Magni, F., Rossoni, G., Berti, F. (1988). BN-52021 protects guinea-pig from heart anaphylaxis. PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 20(supplement 5), 75-78.
BN-52021 protects guinea-pig from heart anaphylaxis
MAGNI, FULVIO;
1988
Abstract
BN-52021 preserves "in vitro" the actively sensitized guinea-pig heart from the immunological reaction. This ginkgolide reduces mediator release (histamine, thromboxane-A2 and slow reacting substance of anaphylaxis) in a dose-dependent manner, particularly that of histamine. These results evidence either an important role for PAF in guinea pig anaphylaxis or a wider spectrum of activity for BN-52021.File in questo prodotto:
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