BN-52021 preserves "in vitro" the actively sensitized guinea-pig heart from the immunological reaction. This ginkgolide reduces mediator release (histamine, thromboxane-A2 and slow reacting substance of anaphylaxis) in a dose-dependent manner, particularly that of histamine. These results evidence either an important role for PAF in guinea pig anaphylaxis or a wider spectrum of activity for BN-52021.

Magni, F., Rossoni, G., Berti, F. (1988). BN-52021 protects guinea-pig from heart anaphylaxis. PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 20(supplement 5), 75-78.

BN-52021 protects guinea-pig from heart anaphylaxis

MAGNI, FULVIO;
1988

Abstract

BN-52021 preserves "in vitro" the actively sensitized guinea-pig heart from the immunological reaction. This ginkgolide reduces mediator release (histamine, thromboxane-A2 and slow reacting substance of anaphylaxis) in a dose-dependent manner, particularly that of histamine. These results evidence either an important role for PAF in guinea pig anaphylaxis or a wider spectrum of activity for BN-52021.
Articolo in rivista - Articolo scientifico
Heart; Animals; Heart Rate; Diterpenes; Guinea Pigs; Anaphylaxis; Thromboxane B2; Lactones; Ginkgolides; Platelet Activating Factor; Male; Histamine
English
1988
20
supplement 5
75
78
none
Magni, F., Rossoni, G., Berti, F. (1988). BN-52021 protects guinea-pig from heart anaphylaxis. PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 20(supplement 5), 75-78.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/36184
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