Bamifylline, a 7-8 disubstituted theophylline derivative, reduces in a dose dependent way (1 x 10(-5) M, 1 x 10(-4) M and 1 x 10(-3) M) the release of histamine, TXB2 (measured also as TXA2-like material) and SRS-A (as LTD4-like material) during the immunological challenge of actively sensitized guinea-pig lungs perfused in vitro. Theophylline was significantly less potent than bamifylline and particularly, at the higher concentrations used (1 x 10(-3) M), bamifylline was 2.7 times more potent than theophylline in reducing the immunological release of histamine and 1.6 and 1.5 times more potent in inhibiting the production of TXB2 and SRS-A, respectively. These data suggest that the ability of the two xanthine derivatives to control the immunological release of histamine represents an important point in understanding the mechanism of their anti-anaphylactic activity.

Berti, F., Magni, F., Rossoni, G., Bongrani, S., Schiantarelli, P. (1990). Pharmacological activity of bamifylline on lung anaphylaxis:In vitro studies. PHARMACOLOGICAL RESEARCH, 22(2), 143-150 [10.1016/1043-6618(90)90710-U].

Pharmacological activity of bamifylline on lung anaphylaxis:In vitro studies

MAGNI, FULVIO;
1990

Abstract

Bamifylline, a 7-8 disubstituted theophylline derivative, reduces in a dose dependent way (1 x 10(-5) M, 1 x 10(-4) M and 1 x 10(-3) M) the release of histamine, TXB2 (measured also as TXA2-like material) and SRS-A (as LTD4-like material) during the immunological challenge of actively sensitized guinea-pig lungs perfused in vitro. Theophylline was significantly less potent than bamifylline and particularly, at the higher concentrations used (1 x 10(-3) M), bamifylline was 2.7 times more potent than theophylline in reducing the immunological release of histamine and 1.6 and 1.5 times more potent in inhibiting the production of TXB2 and SRS-A, respectively. These data suggest that the ability of the two xanthine derivatives to control the immunological release of histamine represents an important point in understanding the mechanism of their anti-anaphylactic activity.
Articolo in rivista - Articolo scientifico
bamifylline; lung anaphylaxis; mediator release;
Animals; Perfusion; Anaphylaxis; Guinea Pigs; SRS-A; Biological Assay; Radioimmunoassay; Thromboxane A2; Lung Diseases; Histamine Release; Bronchodilator Agents; Male; Theophylline
English
1990
22
2
143
150
none
Berti, F., Magni, F., Rossoni, G., Bongrani, S., Schiantarelli, P. (1990). Pharmacological activity of bamifylline on lung anaphylaxis:In vitro studies. PHARMACOLOGICAL RESEARCH, 22(2), 143-150 [10.1016/1043-6618(90)90710-U].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/36177
Citazioni
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 2
Social impact