ive hundred and sixty-six women, consecutively admitted to nine different hospitals for elective abdominal hysterectomy, were randomized to receive a single 2 g i.v. dose of either cefotetan or piperacillin at induction of anesthesia. Five patients were excluded and 561 (287 given cefotetan and 274 given piperacillin) could be evaluated. In 10 patients (5 for each drug) the concentrations of either cefotetan or piperacillin in serum and subcutaneous tissue at the beginning and at the end of surgery andin uterus, salpinx and ovary samples, were microbiologically assessed. Adverse events to prophylactic drugs were never observed. No significant differences could be found between cefotetan and piperacilin groups for any of the considered infectious complications (bacteremia, wound or vaginal cuff infection, pelvic cellulitis and febrile morbidity) nor for the pooled data (cefotetan group: 4.9%, piperacillin group: 5.8%, p:NS). As for the concentrations of prophylactic drugs, serum levels throughout surgery were found to be adequate

Delalla, F., Tassi, P., Conturso, R., Archetti, L., Zanella, G., Meregalli, V., et al. (1993). Piperacillin versus Cefotetan as single-dose prophylaxis in abdominal hysterectomy. A prospective, randomized, multicenter study. JOURNAL OF CHEMOTHERAPY, 5(2), 113-118 [10.1080/1120009x.1993.11739218].

Piperacillin versus Cefotetan as single-dose prophylaxis in abdominal hysterectomy. A prospective, randomized, multicenter study

MILANI, RODOLFO;
1993

Abstract

ive hundred and sixty-six women, consecutively admitted to nine different hospitals for elective abdominal hysterectomy, were randomized to receive a single 2 g i.v. dose of either cefotetan or piperacillin at induction of anesthesia. Five patients were excluded and 561 (287 given cefotetan and 274 given piperacillin) could be evaluated. In 10 patients (5 for each drug) the concentrations of either cefotetan or piperacillin in serum and subcutaneous tissue at the beginning and at the end of surgery andin uterus, salpinx and ovary samples, were microbiologically assessed. Adverse events to prophylactic drugs were never observed. No significant differences could be found between cefotetan and piperacilin groups for any of the considered infectious complications (bacteremia, wound or vaginal cuff infection, pelvic cellulitis and febrile morbidity) nor for the pooled data (cefotetan group: 4.9%, piperacillin group: 5.8%, p:NS). As for the concentrations of prophylactic drugs, serum levels throughout surgery were found to be adequate
Articolo in rivista - Articolo scientifico
Abdominal hysterectomy; Prophylaxis; Piperacillin; Cefotetan
English
1993
5
2
113
118
none
Delalla, F., Tassi, P., Conturso, R., Archetti, L., Zanella, G., Meregalli, V., et al. (1993). Piperacillin versus Cefotetan as single-dose prophylaxis in abdominal hysterectomy. A prospective, randomized, multicenter study. JOURNAL OF CHEMOTHERAPY, 5(2), 113-118 [10.1080/1120009x.1993.11739218].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/35912
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