This study was designed to determine if the efficiency of in-vitro maturation (IVM) in women with normal ovaries can be improved by gonadotrophin administration. 400 women were randomly allocated in four groups: group A, non-primed cycles; group B, human chorionic gonadotrophin (HCG)-primed cycles; group C, FSH-primed cycles; and group D, FSH- plus HCG-primed cycles. There were significant differences in the IVM rate among the groups. In groups where HCG was used, the overall maturation rate was higher (57.9% in group B and 77.4% in group D; 48.4% in group A and 50.8% in group C) and the percentage of total available metaphase II-stage oocytes was higher (60.4% in group B and 82.1% in group D; 48.4% in group A and 50.8% in group C). The overall clinical pregnancy rate per transfer (CPR) was 18.3% and the implantation rate (IR) was 10.6%. There was a difference in CPR among the groups: group D (29.9%) versus group A (15.3%), P = 0.023; group D versus group B (7.6%), P < 0.0001; group D versus group C (17.3%), P = 0.046. The results of this study are clearly in favour of FSH plus HCG priming. FSH priming and HCG priming alone showed no significant effects on clinical outcome.

Fadini, R., Dal Canto, M., Mignini Renzini, M., Brambillasca, F., Comi, R., Fumagalli, D., et al. (2009). Effect of different gonadotrophin priming on IVM of oocytes from women with normal ovaries: a prospective randomized study. REPRODUCTIVE BIOMEDICINE ONLINE, 19(3), 343-351 [10.1016/S1472-6483(10)60168-X].

Effect of different gonadotrophin priming on IVM of oocytes from women with normal ovaries: a prospective randomized study

MILANI, RODOLFO;De Ponti, E.
2009

Abstract

This study was designed to determine if the efficiency of in-vitro maturation (IVM) in women with normal ovaries can be improved by gonadotrophin administration. 400 women were randomly allocated in four groups: group A, non-primed cycles; group B, human chorionic gonadotrophin (HCG)-primed cycles; group C, FSH-primed cycles; and group D, FSH- plus HCG-primed cycles. There were significant differences in the IVM rate among the groups. In groups where HCG was used, the overall maturation rate was higher (57.9% in group B and 77.4% in group D; 48.4% in group A and 50.8% in group C) and the percentage of total available metaphase II-stage oocytes was higher (60.4% in group B and 82.1% in group D; 48.4% in group A and 50.8% in group C). The overall clinical pregnancy rate per transfer (CPR) was 18.3% and the implantation rate (IR) was 10.6%. There was a difference in CPR among the groups: group D (29.9%) versus group A (15.3%), P = 0.023; group D versus group B (7.6%), P < 0.0001; group D versus group C (17.3%), P = 0.046. The results of this study are clearly in favour of FSH plus HCG priming. FSH priming and HCG priming alone showed no significant effects on clinical outcome.
Articolo in rivista - Articolo scientifico
Embryonic Development; Drug Administration Schedule; Embryo Implantation; Ovary; Humans; Gonadotropins; Embryo Transfer; Health; Chorionic Gonadotropin; Drug Combinations; Pregnancy; Follicle Stimulating Hormone; Pregnancy Rate; Cells, Cultured; Fertility Agents, Female; Adult; Oocytes; Oogenesis; Female
English
2009
19
3
343
351
none
Fadini, R., Dal Canto, M., Mignini Renzini, M., Brambillasca, F., Comi, R., Fumagalli, D., et al. (2009). Effect of different gonadotrophin priming on IVM of oocytes from women with normal ovaries: a prospective randomized study. REPRODUCTIVE BIOMEDICINE ONLINE, 19(3), 343-351 [10.1016/S1472-6483(10)60168-X].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/35908
Citazioni
  • Scopus 137
  • ???jsp.display-item.citation.isi??? 126
Social impact