Monotherapy is certainly the best choice for the treatment of all types of epilepsy. In severe epilepsies, when one-drug treatments do not obtain seizure control, a second drug is generally used in order to reach a best clinical outcome, but the real advantage of polytherapy versus monotherapy is still not known in these cases. A retrospective survey was carried out on 66 adult patients with different types of epilepsy who had taken two-drug therapy after failure of the initial monotherapy. With polytherapy, only 16.5% of cases showed a reduction in seizure frequency of 75%, 67% showed no modification and in another 16.5% an increase in seizure frequency of 100% was observed. Polytherapy seems to be not more effective of monotherapy in severe epilepsies in order to obtain a best clinical outcome
Canger, R., Amaud, L., Canevini, M., Cornaggia, C., Pinelli, P., Pruneri, C. (1984). Monoterapia e politerapia nelle epilessie farmacoresistenti. In R. Canger, C.M. Cornaggia, C. Dravet, G. Avanzini, R. Mutani (a cura di), Progressi in epilettologia 1984 (pp. 359-361). Lega italiana contro l'epilessia.
Monoterapia e politerapia nelle epilessie farmacoresistenti
Cornaggia, CM;
1984
Abstract
Monotherapy is certainly the best choice for the treatment of all types of epilepsy. In severe epilepsies, when one-drug treatments do not obtain seizure control, a second drug is generally used in order to reach a best clinical outcome, but the real advantage of polytherapy versus monotherapy is still not known in these cases. A retrospective survey was carried out on 66 adult patients with different types of epilepsy who had taken two-drug therapy after failure of the initial monotherapy. With polytherapy, only 16.5% of cases showed a reduction in seizure frequency of 75%, 67% showed no modification and in another 16.5% an increase in seizure frequency of 100% was observed. Polytherapy seems to be not more effective of monotherapy in severe epilepsies in order to obtain a best clinical outcomeI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.