In this paper, the plasma glucose regulation problem for type 2 diabetic patients is studied. A nonlinear time-delay model of the glucose–insulin regulatory system is exploited to design a quantized sampled-data static output feedback control, using only glucose measurements. It is shown that the proposed control law achieves semiglobal practical stability of the related quantized sampled-data closed-loop glucose–insulin system with arbitrary small steady-state tracking error. The controller involves past values of the glucose, which may not be available in the buffer, for instance because of non-uniform sampling. Such a drawback is overcome by means of spline interpolation. Furthermore, quantization in both input and output channels are taken into account. A pre-clinical validation, concerning the performances of the proposed glucose regulator, is carried out by means of a well-known simulator of diabetic patients, broadly accepted for testing insulin infusion therapies. The simulation results pave the way for further clinical evaluation.

Di Ferdinando, M., Pepe, P., Di Gennaro, S., Borri, A., Palumbo, P. (2021). Quantized sampled-data static output feedback control of the glucose–insulin system. CONTROL ENGINEERING PRACTICE, 112 [10.1016/j.conengprac.2021.104828].

Quantized sampled-data static output feedback control of the glucose–insulin system

Palumbo P.
Ultimo
2021

Abstract

In this paper, the plasma glucose regulation problem for type 2 diabetic patients is studied. A nonlinear time-delay model of the glucose–insulin regulatory system is exploited to design a quantized sampled-data static output feedback control, using only glucose measurements. It is shown that the proposed control law achieves semiglobal practical stability of the related quantized sampled-data closed-loop glucose–insulin system with arbitrary small steady-state tracking error. The controller involves past values of the glucose, which may not be available in the buffer, for instance because of non-uniform sampling. Such a drawback is overcome by means of spline interpolation. Furthermore, quantization in both input and output channels are taken into account. A pre-clinical validation, concerning the performances of the proposed glucose regulator, is carried out by means of a well-known simulator of diabetic patients, broadly accepted for testing insulin infusion therapies. The simulation results pave the way for further clinical evaluation.
Articolo in rivista - Articolo scientifico
Glucose–insulin model; In silico validation; Nonlinear time-delay systems; Quantized sampled-data static output feedback controllers; Stabilization in the sample-and-hold sense;
English
Di Ferdinando, M., Pepe, P., Di Gennaro, S., Borri, A., Palumbo, P. (2021). Quantized sampled-data static output feedback control of the glucose–insulin system. CONTROL ENGINEERING PRACTICE, 112 [10.1016/j.conengprac.2021.104828].
Di Ferdinando, M; Pepe, P; Di Gennaro, S; Borri, A; Palumbo, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/356595
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