The ALL SCTped 2012 FORUM (For Omitting Radiation Under Majority age) trial compared outcomes for children ≥4 years of age transplanted for acute lymphoblastic leukaemia (ALL) who were randomised to myeloablation with a total body irradiation (TBI)-based or chemotherapy-based conditioning regimen. The TBI-based preparation was associated with a lower rate of relapse compared with chemoconditioning. Nevertheless, the age considered suitable for TBI was progressively raised over time to spare the most fragile youngest patients from irradiation-related complications. The best approach to use for children [removed]1 year but <4 years often resemble those presented by older children. In this review, we explore the state of the art regarding haematopoietic stem cell transplantation (HSCT) in children <4 years, the preparative regimens available, and new developments in the field that may influence treatment decisions.

Balduzzi, A., Buechner, J., Ifversen, M., Dalle, J., Colita, A., Bierings, M. (2022). Acute Lymphoblastic Leukaemia in the Youngest: Haematopoietic Stem Cell Transplantation and Beyond. FRONTIERS IN PEDIATRICS, 10 [10.3389/fped.2022.807992].

Acute Lymphoblastic Leukaemia in the Youngest: Haematopoietic Stem Cell Transplantation and Beyond

Balduzzi, Adriana
;
2022

Abstract

The ALL SCTped 2012 FORUM (For Omitting Radiation Under Majority age) trial compared outcomes for children ≥4 years of age transplanted for acute lymphoblastic leukaemia (ALL) who were randomised to myeloablation with a total body irradiation (TBI)-based or chemotherapy-based conditioning regimen. The TBI-based preparation was associated with a lower rate of relapse compared with chemoconditioning. Nevertheless, the age considered suitable for TBI was progressively raised over time to spare the most fragile youngest patients from irradiation-related complications. The best approach to use for children [removed]1 year but <4 years often resemble those presented by older children. In this review, we explore the state of the art regarding haematopoietic stem cell transplantation (HSCT) in children <4 years, the preparative regimens available, and new developments in the field that may influence treatment decisions.
Articolo in rivista - Articolo scientifico
acute lymphoblastic leukaemia (All); blinatumomab; children; chimeric antigen receptor T-cells (CAR T cells); FORUM trial; haematopoietic stem cell transplantation (HSCT); infants; total body irradiation (TBI);
English
Balduzzi, A., Buechner, J., Ifversen, M., Dalle, J., Colita, A., Bierings, M. (2022). Acute Lymphoblastic Leukaemia in the Youngest: Haematopoietic Stem Cell Transplantation and Beyond. FRONTIERS IN PEDIATRICS, 10 [10.3389/fped.2022.807992].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/356372
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