The ALL SCTped 2012 FORUM (For Omitting Radiation Under Majority age) trial compared outcomes for children ≥4 years of age transplanted for acute lymphoblastic leukaemia (ALL) who were randomised to myeloablation with a total body irradiation (TBI)-based or chemotherapy-based conditioning regimen. The TBI-based preparation was associated with a lower rate of relapse compared with chemoconditioning. Nevertheless, the age considered suitable for TBI was progressively raised over time to spare the most fragile youngest patients from irradiation-related complications. The best approach to use for children [removed]1 year but <4 years often resemble those presented by older children. In this review, we explore the state of the art regarding haematopoietic stem cell transplantation (HSCT) in children <4 years, the preparative regimens available, and new developments in the field that may influence treatment decisions.

Balduzzi, A., Buechner, J., Ifversen, M., Dalle, J., Colita, A., & Bierings, M. (2022). Acute Lymphoblastic Leukaemia in the Youngest: Haematopoietic Stem Cell Transplantation and Beyond. FRONTIERS IN PEDIATRICS, 10 [10.3389/fped.2022.807992].

Acute Lymphoblastic Leukaemia in the Youngest: Haematopoietic Stem Cell Transplantation and Beyond

Balduzzi, Adriana
;
2022

Abstract

The ALL SCTped 2012 FORUM (For Omitting Radiation Under Majority age) trial compared outcomes for children ≥4 years of age transplanted for acute lymphoblastic leukaemia (ALL) who were randomised to myeloablation with a total body irradiation (TBI)-based or chemotherapy-based conditioning regimen. The TBI-based preparation was associated with a lower rate of relapse compared with chemoconditioning. Nevertheless, the age considered suitable for TBI was progressively raised over time to spare the most fragile youngest patients from irradiation-related complications. The best approach to use for children [removed]1 year but <4 years often resemble those presented by older children. In this review, we explore the state of the art regarding haematopoietic stem cell transplantation (HSCT) in children <4 years, the preparative regimens available, and new developments in the field that may influence treatment decisions.
Si
Articolo in rivista - Articolo scientifico
Scientifica
acute lymphoblastic leukaemia (All); blinatumomab; children; chimeric antigen receptor T-cells (CAR T cells); FORUM trial; haematopoietic stem cell transplantation (HSCT); infants; total body irradiation (TBI);
English
Balduzzi, A., Buechner, J., Ifversen, M., Dalle, J., Colita, A., & Bierings, M. (2022). Acute Lymphoblastic Leukaemia in the Youngest: Haematopoietic Stem Cell Transplantation and Beyond. FRONTIERS IN PEDIATRICS, 10 [10.3389/fped.2022.807992].
Balduzzi, A; Buechner, J; Ifversen, M; Dalle, J; Colita, A; Bierings, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/356372
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