This review highlights the importance and the complexity of tumour biology and microenvironment in the progression and therapy resistance of glioma. Specific gene mutations, the possible functions of several non-coding microRNAs and the intra-tumour and inter-tumour heterogeneity of cell types contribute to limit the efficacy of the actual therapeutic options. In this scenario, identification of molecular biomarkers of response and the use of multimodal in vivo imaging and in particular the Positron Emission Tomography (PET) based molecular approach, can help identifying glioma features and the modifications occurring during therapy at a regional level. Indeed, a better understanding of tumor heterogeneity and the development of diagnostic procedures can favor the identification of a cluster of patients for personalized medicine in order to improve the survival and their quality of life.

Valtorta, S., Salvatore, D., Rainone, P., Belloli, S., Bertoli, G., Moresco, R. (2020). Molecular and cellular complexity of glioma. Focus on tumour microenvironment and the use of molecular and imaging biomarkers to overcome treatment resistance. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(16), 1-44 [10.3390/ijms21165631].

Molecular and cellular complexity of glioma. Focus on tumour microenvironment and the use of molecular and imaging biomarkers to overcome treatment resistance

Salvatore D.;Rainone P.;Moresco R. M.
2020

Abstract

This review highlights the importance and the complexity of tumour biology and microenvironment in the progression and therapy resistance of glioma. Specific gene mutations, the possible functions of several non-coding microRNAs and the intra-tumour and inter-tumour heterogeneity of cell types contribute to limit the efficacy of the actual therapeutic options. In this scenario, identification of molecular biomarkers of response and the use of multimodal in vivo imaging and in particular the Positron Emission Tomography (PET) based molecular approach, can help identifying glioma features and the modifications occurring during therapy at a regional level. Indeed, a better understanding of tumor heterogeneity and the development of diagnostic procedures can favor the identification of a cluster of patients for personalized medicine in order to improve the survival and their quality of life.
Articolo in rivista - Review Essay
Cell heterogeneity; Glioma; MiRNA; Molecular imaging; PET; Predictive biomarkers; Prognostic biomarkers; Therapy resistance; Tumor-microenvironment;
English
1
44
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Valtorta, S., Salvatore, D., Rainone, P., Belloli, S., Bertoli, G., Moresco, R. (2020). Molecular and cellular complexity of glioma. Focus on tumour microenvironment and the use of molecular and imaging biomarkers to overcome treatment resistance. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(16), 1-44 [10.3390/ijms21165631].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/355824
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