Objective: To develop a new composite disease activity score for gout and provide its first validation. Methods: Disease activity has been defined as the ongoing presence of urate deposits that lead to acute arthritis and joint damage. Every measure for each Outcome Measures in Rheumatology core domain was considered. A 3-step approach (factor analysis, linear discriminant analysis, and linear regression) was applied to derive the Gout Activity Score (GAS). Decision to change treatment or 6-month flare count were used as the surrogate criteria of high disease activity. Baseline and 12-month followup data of 446 patients included in the Kick-Off of the Italian Network for Gout cohort were used. Construct- and criterion-related validity were tested. External validation on an independent sample is reported. Results: Factor analysis identified 5 factors: patient-reported outcomes, joint examination, flares, tophi, and serum uric acid (sUA). Discriminant function analysis resulted in a correct classification of 79%. Linear regression analysis identified a first candidate GAS including 12-month flare count, sUA, visual analog scale (VAS) of pain, VAS global activity assessment, swollen and tender joint counts, and a cumulative measure of tophi. Alternative scores were also developed. The developed GAS demonstrated a good correlation with functional disability (criterion validity) and discrimination between patient- and physician-reported measures of active disease (construct validity). The results were reproduced in the external sample. Conclusion: This study developed and validated a composite measure of disease activity in gout. Further testing is required to confirm its generalizability, responsiveness, and usefulness in assisting with clinical decisions.

Scire, C., Carrara, G., Viroli, C., Cimmino, M., Taylor, W., Manara, M., et al. (2016). Development and First Validation of a Disease Activity Score for Gout. ARTHRITIS CARE & RESEARCH, 68(10), 1530-1537 [10.1002/acr.22844].

Development and First Validation of a Disease Activity Score for Gout

Scire C. A.
Primo
;
2016

Abstract

Objective: To develop a new composite disease activity score for gout and provide its first validation. Methods: Disease activity has been defined as the ongoing presence of urate deposits that lead to acute arthritis and joint damage. Every measure for each Outcome Measures in Rheumatology core domain was considered. A 3-step approach (factor analysis, linear discriminant analysis, and linear regression) was applied to derive the Gout Activity Score (GAS). Decision to change treatment or 6-month flare count were used as the surrogate criteria of high disease activity. Baseline and 12-month followup data of 446 patients included in the Kick-Off of the Italian Network for Gout cohort were used. Construct- and criterion-related validity were tested. External validation on an independent sample is reported. Results: Factor analysis identified 5 factors: patient-reported outcomes, joint examination, flares, tophi, and serum uric acid (sUA). Discriminant function analysis resulted in a correct classification of 79%. Linear regression analysis identified a first candidate GAS including 12-month flare count, sUA, visual analog scale (VAS) of pain, VAS global activity assessment, swollen and tender joint counts, and a cumulative measure of tophi. Alternative scores were also developed. The developed GAS demonstrated a good correlation with functional disability (criterion validity) and discrimination between patient- and physician-reported measures of active disease (construct validity). The results were reproduced in the external sample. Conclusion: This study developed and validated a composite measure of disease activity in gout. Further testing is required to confirm its generalizability, responsiveness, and usefulness in assisting with clinical decisions.
Articolo in rivista - Articolo scientifico
gout;
English
1530
1537
8
Scire, C., Carrara, G., Viroli, C., Cimmino, M., Taylor, W., Manara, M., et al. (2016). Development and First Validation of a Disease Activity Score for Gout. ARTHRITIS CARE & RESEARCH, 68(10), 1530-1537 [10.1002/acr.22844].
Scire, C; Carrara, G; Viroli, C; Cimmino, M; Taylor, W; Manara, M; Govoni, M; Salaffi, F; Punzi, L; Montecucco, C; Matucci-Cerinic, M; Minisola, G; Ariani, A; Galossi, A; Lauriti, C; Fracassi, E; Idolazzi, L; Bardelli, M; Selvi, E; Tirri, E; Furini, F; Inverardi, F; Calabro, A; Porta, F; Bittelli, R; Venturino, F; Capsoni, F; Prevete, I; Sebastiani, G; Selmi, C; Fabbriciani, G; D'Avola, G; Botticella, G; Serale, F; Seminara, G; D'Alessandro, G; Santo, L; Longato, L; Zaccara, E; Sinigaglia, L; Atteritano, M; Broggini, M; Caprioli, M; Favero, M; Salli, S; Scarati, M; Parisi, S; Malavolta, N; Corvaglia, S; Scarpato, S; Veneto, V
File in questo prodotto:
File Dimensione Formato  
Scirè et al. - 2016 - Development and First Validation of a Disease Acti.pdf

accesso aperto

Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Dimensione 383.86 kB
Formato Adobe PDF
383.86 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/355311
Citazioni
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 18
Social impact