In a pilot study, proglumide, a cholecystokinin receptor antagonist, was administered to 8 patients affected from Huntington's chorea under long-term haloperidol treatment. The effectiveness of haloperidol on chronic symptomatology was reduced by the concomitant administration of proglumide; the latter drug, when administered alone, did not modify the severity of chorea compared to placebo. Possible explanations of these results are discussed, stressing the modulatory role of CCK not only on the dopaminergic, but also on the GABAergic system.

Piolti, R., Appollonio, I., Perego, M., Pozzi, C., Rovati, L., Ferrarese, C., et al. (1995). Proglumide, a cholecystokinin receptor antagonist, reduces neuroleptic action in Huntington's chorea. EUROPEAN NEUROLOGY, 35(6), 344-348.

Proglumide, a cholecystokinin receptor antagonist, reduces neuroleptic action in Huntington's chorea

APPOLLONIO, ILDEBRANDO;FERRARESE, CARLO;
1995

Abstract

In a pilot study, proglumide, a cholecystokinin receptor antagonist, was administered to 8 patients affected from Huntington's chorea under long-term haloperidol treatment. The effectiveness of haloperidol on chronic symptomatology was reduced by the concomitant administration of proglumide; the latter drug, when administered alone, did not modify the severity of chorea compared to placebo. Possible explanations of these results are discussed, stressing the modulatory role of CCK not only on the dopaminergic, but also on the GABAergic system.
Articolo in rivista - Articolo scientifico
Scientifica
Severity of Illness Index; Humans; Aged; Pilot Projects; Antipsychotic Agents; Drug Therapy, Combination; Haloperidol; Receptors, Cholecystokinin; Adult; Middle Aged; Proglumide; Adolescent; Female; Huntington Disease; Male
English
Piolti, R., Appollonio, I., Perego, M., Pozzi, C., Rovati, L., Ferrarese, C., et al. (1995). Proglumide, a cholecystokinin receptor antagonist, reduces neuroleptic action in Huntington's chorea. EUROPEAN NEUROLOGY, 35(6), 344-348.
Piolti, R; Appollonio, I; Perego, M; Pozzi, C; Rovati, L; Ferrarese, C; Frattola, L
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/35425
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