Utilization of endoscopy to both visualize and selectively biopsy an intestinal allograft has become the standard for early recognition and treatment of intestinal allograft rejection. Despite the widespread acceptance of the need for selective mucosal biopsies, it has not been shown that the histological features of intestinal allograft rejection are either localized or occur as part of a more diffuse phenomenon within a tubular allograft. To resolve these issues, 88 ileoscopies were performed in 12 small-bowel allograft recipients and mucosal biopsy samples were obtained at 5, 10, and 15 cm, respectively, from the ileal stoma. Each mucosal biopsy was labeled, processed, and evaluated individually for the presence and severity of any evidence for allograft rejection. The data obtained suggest that intestinal allograft rejection is a diffuse process, and biopsies obtained randomly from an ileal graft are likely to demonstrate evidence of allograft rejection when such is present.

Gurakar, A., Fagiuoli, S., Hassanein, T., Wright, H., Balkan, M., Frezza, E., et al. (1994). Is rejection a diffuse or localized process in small-bowel transplantation?. SURGICAL ENDOSCOPY, 8(7), 762-764 [10.1007/BF00593436].

Is rejection a diffuse or localized process in small-bowel transplantation?

Fagiuoli S;
1994

Abstract

Utilization of endoscopy to both visualize and selectively biopsy an intestinal allograft has become the standard for early recognition and treatment of intestinal allograft rejection. Despite the widespread acceptance of the need for selective mucosal biopsies, it has not been shown that the histological features of intestinal allograft rejection are either localized or occur as part of a more diffuse phenomenon within a tubular allograft. To resolve these issues, 88 ileoscopies were performed in 12 small-bowel allograft recipients and mucosal biopsy samples were obtained at 5, 10, and 15 cm, respectively, from the ileal stoma. Each mucosal biopsy was labeled, processed, and evaluated individually for the presence and severity of any evidence for allograft rejection. The data obtained suggest that intestinal allograft rejection is a diffuse process, and biopsies obtained randomly from an ileal graft are likely to demonstrate evidence of allograft rejection when such is present.
Articolo in rivista - Articolo scientifico
Acute cellular rejection; Biopsy; Ileoscopy; Intestinal rejection; Small-bowel transplantation;
English
762
764
3
Gurakar, A., Fagiuoli, S., Hassanein, T., Wright, H., Balkan, M., Frezza, E., et al. (1994). Is rejection a diffuse or localized process in small-bowel transplantation?. SURGICAL ENDOSCOPY, 8(7), 762-764 [10.1007/BF00593436].
Gurakar, A; Fagiuoli, S; Hassanein, T; Wright, H; Balkan, M; Frezza, E; Todo, S; Starzl, T; Van Thiel, D
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/354009
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