Background. Liver transplantation is the standard treatment for patients with end-stage liver disease no longer responsive to conventional medical treatment Aims. To report the long-term experience of liver transplantation in Italy. Patients and Methods. Data were obtained retrospectively by means of a multiple-item form collected from 15 Italian liver transplant centres. The filing centre was centralized. Results. A total of 3323 liver transplants were performed on 3026 patients, with a cumulative proportional survival of 72.4%. Three, 5 and 10 years'patient survival rates were 72.3%, 68.8% and 61.3%, respectively. The most common indication for liver transplantation were hepatitis B virus (± hepatitis D virus]- and hepatitis C virus-related cirrhosis (59.4%). Excellent survival rates were observed particularly in controversial indications, such as alcoholic cirrhosis, hepatitis B virus-related cirrhosis and hepatocellular carcinoma. Retransplantation was required in 8.9% of the cases. The overall prevalence of acute cellular rejection episodes was 43.5%. In our study population, primary non-function and disease recurrence were the most common causes of graft failure (28.7% and 25.4%, respectively). Infections and/or sepsis were the most common causes of death after transplantation (42%). Conclusion. This study confirms that patients with controversial indications to liver transplantation such as alcoholic cirrhosis, HBV-related cirrhosis and hepatocellular carcinoma can achieve excellent survival when properly selected.

Fagiuoli, S., Mirante, V., Pompili, M., Gianni, S., Leandro, G., Rapaccini, G., et al. (2002). Liver transplantation: the Italian experience. DIGESTIVE AND LIVER DISEASE, 34(9), 640-648 [10.1016/S1590-8658(02)80207-9].

Liver transplantation: the Italian experience

Fagiuoli S
;
2002

Abstract

Background. Liver transplantation is the standard treatment for patients with end-stage liver disease no longer responsive to conventional medical treatment Aims. To report the long-term experience of liver transplantation in Italy. Patients and Methods. Data were obtained retrospectively by means of a multiple-item form collected from 15 Italian liver transplant centres. The filing centre was centralized. Results. A total of 3323 liver transplants were performed on 3026 patients, with a cumulative proportional survival of 72.4%. Three, 5 and 10 years'patient survival rates were 72.3%, 68.8% and 61.3%, respectively. The most common indication for liver transplantation were hepatitis B virus (± hepatitis D virus]- and hepatitis C virus-related cirrhosis (59.4%). Excellent survival rates were observed particularly in controversial indications, such as alcoholic cirrhosis, hepatitis B virus-related cirrhosis and hepatocellular carcinoma. Retransplantation was required in 8.9% of the cases. The overall prevalence of acute cellular rejection episodes was 43.5%. In our study population, primary non-function and disease recurrence were the most common causes of graft failure (28.7% and 25.4%, respectively). Infections and/or sepsis were the most common causes of death after transplantation (42%). Conclusion. This study confirms that patients with controversial indications to liver transplantation such as alcoholic cirrhosis, HBV-related cirrhosis and hepatocellular carcinoma can achieve excellent survival when properly selected.
Articolo in rivista - Articolo scientifico
Liver disease; Liver transplantation;
English
640
648
9
Fagiuoli, S., Mirante, V., Pompili, M., Gianni, S., Leandro, G., Rapaccini, G., et al. (2002). Liver transplantation: the Italian experience. DIGESTIVE AND LIVER DISEASE, 34(9), 640-648 [10.1016/S1590-8658(02)80207-9].
Fagiuoli, S; Mirante, V; Pompili, M; Gianni, S; Leandro, G; Rapaccini, G; Gasbarrini, A; Naccarato, R; Pagliaro, L; Rizzetto, M; Gasbarrini, G; Monotematica AISF 2000-OLT Study, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/353717
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