Background: Survival in HCC depends on diagnosis at early tumor stage, best achieved through surveillance radiology. There is also a need for complementary serum tests. Methods: We evaluated baseline liver function parameters from a cohort of 231 HCC patients who were diagnosed by surveillance. They were ordered according to their tumor mass and trends in the data were analyzed. Results: Trends in serum GGTP levels increased linearly with increases in small tumor mass, but the patterns for AFP levels were more complex and elevated only with larger tumor mass. ALKP levels were elevated in association with small tumors and further increased with increasing tumor mass. The relationships of serum AFP to GGTP, of albumin to bilirubin and of ALKP to bilirubin, helped identify tumor mass phenotypes. There was an especially important relationship between serum bilirubin and AFP, suggesting that HCC growth and liver factors were interdependent. Conclusions: Small HCCs demonstrated several phenotypic sub-groups, with serum GGTP and ALKP increasing and albumin decreasing in many patients with increasing tumor mass.

Pancoska, P., De Giorgio, M., Fagiuoli, S., Carr, B. (2011). Small HCCs identified by screening. DIGESTIVE DISEASES AND SCIENCES, 56(10), 3078-3085 [10.1007/s10620-011-1687-x].

Small HCCs identified by screening

Fagiuoli S;
2011

Abstract

Background: Survival in HCC depends on diagnosis at early tumor stage, best achieved through surveillance radiology. There is also a need for complementary serum tests. Methods: We evaluated baseline liver function parameters from a cohort of 231 HCC patients who were diagnosed by surveillance. They were ordered according to their tumor mass and trends in the data were analyzed. Results: Trends in serum GGTP levels increased linearly with increases in small tumor mass, but the patterns for AFP levels were more complex and elevated only with larger tumor mass. ALKP levels were elevated in association with small tumors and further increased with increasing tumor mass. The relationships of serum AFP to GGTP, of albumin to bilirubin and of ALKP to bilirubin, helped identify tumor mass phenotypes. There was an especially important relationship between serum bilirubin and AFP, suggesting that HCC growth and liver factors were interdependent. Conclusions: Small HCCs demonstrated several phenotypic sub-groups, with serum GGTP and ALKP increasing and albumin decreasing in many patients with increasing tumor mass.
Articolo in rivista - Articolo scientifico
ALKP; GGTP; HCC; Small tumors; Surveillance; Tumor mass;
English
3078
3085
8
Pancoska, P., De Giorgio, M., Fagiuoli, S., Carr, B. (2011). Small HCCs identified by screening. DIGESTIVE DISEASES AND SCIENCES, 56(10), 3078-3085 [10.1007/s10620-011-1687-x].
Pancoska, P; De Giorgio, M; Fagiuoli, S; Carr, B
File in questo prodotto:
File Dimensione Formato  
DDS pancowska 20111.pdf

Solo gestori archivio

Dimensione 2.21 MB
Formato Adobe PDF
2.21 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/353715
Citazioni
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 5
Social impact