Reactive Oxygen Species (ROS) may be involved in the damage occurring in the course of chronic HCV infection. Individuals with chronic hepatitis C present increased hepatic levels of malondialdehyde (MDA) and reduced levels of glutathione. To determine whether these observations are associated with serological evidence for ROS injury, MDA and protein carbonyl content (PCC) of serum was determined in 20 HCV positive patients (14 chronic active hepatitis-CAH and 6 cirrhosis) and 20 controls. Compared to controls, HCV positive subjects had increased levels of MDA (13.33 ± 0.21 SE ng/ml vs. 9.90 ± 0.65, P < .05) and PCC (4.74 ± 0.21 nmol/mg vs. 3.68 ± 0.21, p < .02). Patients with CAH had higher levels than did cirrhotics. Both MDA and PCC correlated with serum ALT levels (r = .792 and r = .818 respectively, p < .001). A common origin for MDA and PCC found in patients with chronic hepatitis C was suggested by the correlation between the two measures (r = .741, p < .001). No correlation were found between MDA or PCC and the hepatic iron content. These data demonstrate that: (1) lipid and protein oxidation occur in chronic hepatitis C, (2) oxidative damage can be demonstrated as increased serum levels of MDA and PCC, and (3) both MDA and PCC levels correlate with disease activity.

De Maria, N., Colantoni, A., Fagiuoli, S., Liu, G., Rogers, B., Farinati, F., et al. (1996). Association between reactive oxygen species and disease activity in chronic hepatitis C. FREE RADICAL BIOLOGY & MEDICINE, 21(3), 291-295 [10.1016/0891-5849(96)00044-5].

Association between reactive oxygen species and disease activity in chronic hepatitis C

Fagiuoli S;
1996

Abstract

Reactive Oxygen Species (ROS) may be involved in the damage occurring in the course of chronic HCV infection. Individuals with chronic hepatitis C present increased hepatic levels of malondialdehyde (MDA) and reduced levels of glutathione. To determine whether these observations are associated with serological evidence for ROS injury, MDA and protein carbonyl content (PCC) of serum was determined in 20 HCV positive patients (14 chronic active hepatitis-CAH and 6 cirrhosis) and 20 controls. Compared to controls, HCV positive subjects had increased levels of MDA (13.33 ± 0.21 SE ng/ml vs. 9.90 ± 0.65, P < .05) and PCC (4.74 ± 0.21 nmol/mg vs. 3.68 ± 0.21, p < .02). Patients with CAH had higher levels than did cirrhotics. Both MDA and PCC correlated with serum ALT levels (r = .792 and r = .818 respectively, p < .001). A common origin for MDA and PCC found in patients with chronic hepatitis C was suggested by the correlation between the two measures (r = .741, p < .001). No correlation were found between MDA or PCC and the hepatic iron content. These data demonstrate that: (1) lipid and protein oxidation occur in chronic hepatitis C, (2) oxidative damage can be demonstrated as increased serum levels of MDA and PCC, and (3) both MDA and PCC levels correlate with disease activity.
Articolo in rivista - Articolo scientifico
Chronic hepatitis; Free radicals; HCV; Hepatotoxicity; Malondialdehyde; Peroxidation; Protein oxidation;
English
291
295
5
De Maria, N., Colantoni, A., Fagiuoli, S., Liu, G., Rogers, B., Farinati, F., et al. (1996). Association between reactive oxygen species and disease activity in chronic hepatitis C. FREE RADICAL BIOLOGY & MEDICINE, 21(3), 291-295 [10.1016/0891-5849(96)00044-5].
De Maria, N; Colantoni, A; Fagiuoli, S; Liu, G; Rogers, B; Farinati, F; Van Thiel, D; Floyd, R
File in questo prodotto:
File Dimensione Formato  
De Maria N. (1996) Association between reactive oxygen species and disease activity in chronic hepatitis C.pdf

Solo gestori archivio

Dimensione 2.66 MB
Formato Adobe PDF
2.66 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/353697
Citazioni
  • Scopus 211
  • ???jsp.display-item.citation.isi??? 189
Social impact