Background: Clinical phenotypes of small and large hepatocellular carcinomas (HCCs) are not well characterized. Aim: To evaluate the characteristics of small HCCs diagnosed by screening. Method: A cohort of 430 small HCCs that were diagnosed through screening, were dichotomized according to a size of ≤3 cm or >3 cm maximum tumor diameter and compared for radiological and blood-test parameters. Results: There were 330 males and 100 females. A higher percent of females had smaller tumors. The majority of patients had single tumors, but 15% of those with larger tumors had portal vein thrombosis (PVT) compared to 5% of those with smaller tumors. Significant differences between the tumor-size groups included alpha-fetoprotein (AFP) values and platelet counts, with thrombocytopenia and elevated bilirubin levels being associated with smaller tumors. In comparing PVT-positive and PVT-negative patients, AFP levels and platelet counts were also significantly different between the 2 groups. A mean multinomial multiple logistic regression model was developed for maximum tumor diameter plus PVT. Conclusions: The finding of larger tumors being associated with normal platelets and bilirubin levels in comparison to smaller tumors having thrombocytopenia reveals 2 different patterns of HCC presentation.

Carr, B., Guerra, V., De Giorgio, M., Fagiuoli, S., Pancoska, P. (2012). Small hepatocellular carcinomas and thrombocytopenia. ONCOLOGY, 83(6), 331-338 [10.1159/000341533].

Small hepatocellular carcinomas and thrombocytopenia

Fagiuoli S;
2012

Abstract

Background: Clinical phenotypes of small and large hepatocellular carcinomas (HCCs) are not well characterized. Aim: To evaluate the characteristics of small HCCs diagnosed by screening. Method: A cohort of 430 small HCCs that were diagnosed through screening, were dichotomized according to a size of ≤3 cm or >3 cm maximum tumor diameter and compared for radiological and blood-test parameters. Results: There were 330 males and 100 females. A higher percent of females had smaller tumors. The majority of patients had single tumors, but 15% of those with larger tumors had portal vein thrombosis (PVT) compared to 5% of those with smaller tumors. Significant differences between the tumor-size groups included alpha-fetoprotein (AFP) values and platelet counts, with thrombocytopenia and elevated bilirubin levels being associated with smaller tumors. In comparing PVT-positive and PVT-negative patients, AFP levels and platelet counts were also significantly different between the 2 groups. A mean multinomial multiple logistic regression model was developed for maximum tumor diameter plus PVT. Conclusions: The finding of larger tumors being associated with normal platelets and bilirubin levels in comparison to smaller tumors having thrombocytopenia reveals 2 different patterns of HCC presentation.
Articolo in rivista - Articolo scientifico
Alpha-fetoprotein; Hepatocellular carcinoma; Portal vein thrombosis; Thrombocytopenia;
English
331
338
8
Carr, B., Guerra, V., De Giorgio, M., Fagiuoli, S., Pancoska, P. (2012). Small hepatocellular carcinomas and thrombocytopenia. ONCOLOGY, 83(6), 331-338 [10.1159/000341533].
Carr, B; Guerra, V; De Giorgio, M; Fagiuoli, S; Pancoska, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/353326
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