Primary biliary cirrhosis is considered a low risk for the development of hepatocellular carcinoma. We evaluated the incidence of hepatocellular carcinoma in a cohort of 89 female primary biliary cirrhosis patients and, as a control group, in 73 female patients with cirrhosis of a different etiology. The patients underwent ultrasound and alfa-fetoprotein determination every 6 months. Two patients developed hepatocellular carcinoma in the primary biliary cirrhosis and three in the control group, respectively. The Relative Risk for hepatocellular carcinoma in primary biliary cirrhosis patients was 0.7. However, when considering only stage IV, primary biliary cirrhosis patients with cirrhosis, the Relative Risk was actually 1.5 with respect to controls, with 1.4% cases of hepatocellular carcinoma per year. These data suggest that the risk of hepatocellular carcinoma is similar in female patients with primary biliary cirrhosis and in female patients with cirrhosis of a different etiology. (C) Journal of Hepatology.

Farinati, F., Floreani, A., De Maria, N., Fagiuoli, S., Naccarato, R., & Chiaramonte, M. (1994). Hepatocellular carcinoma in primary biliary cirrhosis. JOURNAL OF HEPATOLOGY, 21(3), 315-316 [10.1016/s0168-8278(05)80307-1].

Hepatocellular carcinoma in primary biliary cirrhosis

Fagiuoli S;
1994

Abstract

Primary biliary cirrhosis is considered a low risk for the development of hepatocellular carcinoma. We evaluated the incidence of hepatocellular carcinoma in a cohort of 89 female primary biliary cirrhosis patients and, as a control group, in 73 female patients with cirrhosis of a different etiology. The patients underwent ultrasound and alfa-fetoprotein determination every 6 months. Two patients developed hepatocellular carcinoma in the primary biliary cirrhosis and three in the control group, respectively. The Relative Risk for hepatocellular carcinoma in primary biliary cirrhosis patients was 0.7. However, when considering only stage IV, primary biliary cirrhosis patients with cirrhosis, the Relative Risk was actually 1.5 with respect to controls, with 1.4% cases of hepatocellular carcinoma per year. These data suggest that the risk of hepatocellular carcinoma is similar in female patients with primary biliary cirrhosis and in female patients with cirrhosis of a different etiology. (C) Journal of Hepatology.
Articolo in rivista - Articolo scientifico
Cancer screening; Chronic cholestatic disorders; Hepatitis C virus; Hepatocellular carcinoma; Liver neoplasm;
English
315
316
2
Farinati, F., Floreani, A., De Maria, N., Fagiuoli, S., Naccarato, R., & Chiaramonte, M. (1994). Hepatocellular carcinoma in primary biliary cirrhosis. JOURNAL OF HEPATOLOGY, 21(3), 315-316 [10.1016/s0168-8278(05)80307-1].
Farinati, F; Floreani, A; De Maria, N; Fagiuoli, S; Naccarato, R; Chiaramonte, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/353315
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