BACKGROUND: Mother-to-child transmission of hepatitis C virus (HCV) has been reported in around 5% of cases, and is much more likely to occur in case of coinfection with HIV. However, other cofactors influencing the vertical transmission are still debated. AIM: To assess the serum concentration of endogenous interferon (IFN) during pregnancy, and its eventual role on the vertical transmission of HCV. METHODS: Forty-seven HCV-infected pregnant women, and 3 control groups: (1) 75 HCV-negative pregnant women; (2) 29 HCV-positive nonpregnant women; (3) 29 HCV-negative nonpregnant women entered into the study. Endogenous IFN was assayed by enzyme-linked immunosorbent assay. The following parameters were also analyzed: viral load, HIV infection, risk factors for acquiring HCV, parity, gestational age, mode and course of delivery. RESULTS: Vertical transmission of HCV was observed in 2 cases (4.3%). Plasma levels of IFN were significantly higher in HCV-positive pregnant women compared with either HCV-positive and HCV-negative nonpregnant women. The 2 mothers who transmitted the infection had IFN levels within the same range as the women who did not transmit the infection. CONCLUSIONS: In HCV-positive pregnant women, there is an increased production of endogenous IFN-α. Further studies are warranted for clarifying the mechanisms of this cytokine in the prevention of HCV transmission. © 2008 Lippincott Williams & Wilkins, Inc.

Paternoster, D., Belligoli, A., Ngaradoumbe, N., Visentin, S., Franco, R., Fagiuoli, S., et al. (2008). Endogenous interferon-alpha level is increased in hepatitis C virus (HCV)-positive pregnant women. JOURNAL OF CLINICAL GASTROENTEROLOGY, 42(2), 204-207 [10.1097/01.mcg.0000247991.81591.2e].

Endogenous interferon-alpha level is increased in hepatitis C virus (HCV)-positive pregnant women

Fagiuoli S;
2008

Abstract

BACKGROUND: Mother-to-child transmission of hepatitis C virus (HCV) has been reported in around 5% of cases, and is much more likely to occur in case of coinfection with HIV. However, other cofactors influencing the vertical transmission are still debated. AIM: To assess the serum concentration of endogenous interferon (IFN) during pregnancy, and its eventual role on the vertical transmission of HCV. METHODS: Forty-seven HCV-infected pregnant women, and 3 control groups: (1) 75 HCV-negative pregnant women; (2) 29 HCV-positive nonpregnant women; (3) 29 HCV-negative nonpregnant women entered into the study. Endogenous IFN was assayed by enzyme-linked immunosorbent assay. The following parameters were also analyzed: viral load, HIV infection, risk factors for acquiring HCV, parity, gestational age, mode and course of delivery. RESULTS: Vertical transmission of HCV was observed in 2 cases (4.3%). Plasma levels of IFN were significantly higher in HCV-positive pregnant women compared with either HCV-positive and HCV-negative nonpregnant women. The 2 mothers who transmitted the infection had IFN levels within the same range as the women who did not transmit the infection. CONCLUSIONS: In HCV-positive pregnant women, there is an increased production of endogenous IFN-α. Further studies are warranted for clarifying the mechanisms of this cytokine in the prevention of HCV transmission. © 2008 Lippincott Williams & Wilkins, Inc.
Articolo in rivista - Articolo scientifico
HCV; Hepatitis C; HIV; Interferon; Vertical transmission;
English
204
207
4
Paternoster, D., Belligoli, A., Ngaradoumbe, N., Visentin, S., Franco, R., Fagiuoli, S., et al. (2008). Endogenous interferon-alpha level is increased in hepatitis C virus (HCV)-positive pregnant women. JOURNAL OF CLINICAL GASTROENTEROLOGY, 42(2), 204-207 [10.1097/01.mcg.0000247991.81591.2e].
Paternoster, D; Belligoli, A; Ngaradoumbe, N; Visentin, S; Franco, R; Fagiuoli, S; Boldrin, C; Palù, G; Baldo, V; Floreani, A
File in questo prodotto:
File Dimensione Formato  
PATERNOSTER J. Cli. Gast.pdf

Solo gestori archivio

Dimensione 132.41 kB
Formato Adobe PDF
132.41 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/353291
Citazioni
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 7
Social impact