Background: The recurrence of hepatitis C viral infection is common after liver transplant, and achieving a sustained virological response to antiviral treatment is desirable for reducing the risk of graft loss and improving patients' survival. Aim: To investigate the long-term maintenance of sustained virological response in liver transplant recipients with hepatitis C recurrence. Methods: 436 Liver transplant recipients (74.1% genotype 1) who underwent combined antiviral therapy for hepatitis C recurrence were retrospectively evaluated. Results: The overall sustained virological response rate was 40% (173/436 patients), and the mean follow-up after liver transplantation was 11. ±. 3.5 years (range, 5-24). Patients with a sustained virological response demonstrated a 5-year survival rate of 97% and a 10-year survival rate of 93%; all but 6 (3%) patients remained hepatitis C virus RNA-negative during follow-up. Genotype non-1 (p= 0.007), treatment duration >80% of the scheduled period (p= 0.027), and early virological response (p= 0.002), were associated with the maintenance of sustained virological response as indicated by univariate analysis. Early virological response was the only independent predictor of sustained virological response maintenance (p= 0.008). Conclusions: Sustained virological response achieved after combined antiviral treatment is maintained in liver transplant patients with recurrent hepatitis C and is associated with an excellent 5-year survival.

Ponziani, F., Fagiuoli, S., Gasbarrini, A., Pompili, M., Vero, V. (2014). Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C. DIGESTIVE AND LIVER DISEASE, 46(5), 440-445 [10.1016/j.dld.2014.01.157].

Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C

Fagiuoli, Stefano;
2014

Abstract

Background: The recurrence of hepatitis C viral infection is common after liver transplant, and achieving a sustained virological response to antiviral treatment is desirable for reducing the risk of graft loss and improving patients' survival. Aim: To investigate the long-term maintenance of sustained virological response in liver transplant recipients with hepatitis C recurrence. Methods: 436 Liver transplant recipients (74.1% genotype 1) who underwent combined antiviral therapy for hepatitis C recurrence were retrospectively evaluated. Results: The overall sustained virological response rate was 40% (173/436 patients), and the mean follow-up after liver transplantation was 11. ±. 3.5 years (range, 5-24). Patients with a sustained virological response demonstrated a 5-year survival rate of 97% and a 10-year survival rate of 93%; all but 6 (3%) patients remained hepatitis C virus RNA-negative during follow-up. Genotype non-1 (p= 0.007), treatment duration >80% of the scheduled period (p= 0.027), and early virological response (p= 0.002), were associated with the maintenance of sustained virological response as indicated by univariate analysis. Early virological response was the only independent predictor of sustained virological response maintenance (p= 0.008). Conclusions: Sustained virological response achieved after combined antiviral treatment is maintained in liver transplant patients with recurrent hepatitis C and is associated with an excellent 5-year survival.
Articolo in rivista - Articolo scientifico
HCV antiviral treatment; Hepatitis C recurrence; Liver transplantation; Sustained viral response;
English
440
445
6
Ponziani, F., Fagiuoli, S., Gasbarrini, A., Pompili, M., Vero, V. (2014). Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C. DIGESTIVE AND LIVER DISEASE, 46(5), 440-445 [10.1016/j.dld.2014.01.157].
Ponziani, F; Fagiuoli, S; Gasbarrini, A; Pompili, M; Vero, V
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/353287
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