Recent reports indicate that hepatitis C virus (HCV) may play a role in the pathogenesis of hepatocellular carcinoma in cirrhotics. Using an ELISA test, we evaluated the prevalence of anti-HCV antibodies in 97 patients with hepatocellular carcinoma (HCC) in cirrhosis and in a group of 223 patients, including: 49 patients with HBsAg-positive chronic liver disease (CLD), 42 with alcoholic CLD, 110 with cryptogenic CLD and 22 with post-transfusional HBsAg-negative CLD. All diagnoses were histologically confirmed. Overall, anti-HCV-positive HCC were 64% of the total, with no statistically significant difference with respect to CLD (60.9%). The prevalence of anti-HCV was higher in cryptogenic HCC (80%) than in HBsAg-positive (60%) or alcoholic HCC (42.8%) (p less than 0.005). When HCC and cirrhosis of similar putative etiology were considered, anti-HCV prevalence was significantly higher in HCC than in cirrhosis only in the groups of patients with alcoholic liver damage (60% in HCC vs. 38% in cirrhosis, p less than 0.005). In HBsAg-positive patients, anti-HCV prevalence was twice as high in HCC than in CLD, but the difference was not statistically significant. Overall, anti-HCV prevalence in HCC was significantly higher than in alcoholic or HBsAg-positive CLD (p less than 0.001 and p less than 0.01, respectively) but lower than in cryptogenic CLD (p less than 0.001). Association between anti-HCV and anti-HBc was significantly more prevalent in patients with CLD than in those with HCC.

Farinati, F., Fagiuoli, S., De Maria, N., Chiaramonte, M., Aneloni, V., Ongaro, S., et al. (1992). Anti-HCV positive hepatocellular carcinoma in cirrhosis. Prevalence, risk factors and clinical features. JOURNAL OF HEPATOLOGY, 14(2-3), 183-187 [10.1016/0168-8278(92)90156-j].

Anti-HCV positive hepatocellular carcinoma in cirrhosis. Prevalence, risk factors and clinical features

Fagiuoli S;
1992

Abstract

Recent reports indicate that hepatitis C virus (HCV) may play a role in the pathogenesis of hepatocellular carcinoma in cirrhotics. Using an ELISA test, we evaluated the prevalence of anti-HCV antibodies in 97 patients with hepatocellular carcinoma (HCC) in cirrhosis and in a group of 223 patients, including: 49 patients with HBsAg-positive chronic liver disease (CLD), 42 with alcoholic CLD, 110 with cryptogenic CLD and 22 with post-transfusional HBsAg-negative CLD. All diagnoses were histologically confirmed. Overall, anti-HCV-positive HCC were 64% of the total, with no statistically significant difference with respect to CLD (60.9%). The prevalence of anti-HCV was higher in cryptogenic HCC (80%) than in HBsAg-positive (60%) or alcoholic HCC (42.8%) (p less than 0.005). When HCC and cirrhosis of similar putative etiology were considered, anti-HCV prevalence was significantly higher in HCC than in cirrhosis only in the groups of patients with alcoholic liver damage (60% in HCC vs. 38% in cirrhosis, p less than 0.005). In HBsAg-positive patients, anti-HCV prevalence was twice as high in HCC than in CLD, but the difference was not statistically significant. Overall, anti-HCV prevalence in HCC was significantly higher than in alcoholic or HBsAg-positive CLD (p less than 0.001 and p less than 0.01, respectively) but lower than in cryptogenic CLD (p less than 0.001). Association between anti-HCV and anti-HBc was significantly more prevalent in patients with CLD than in those with HCC.
Articolo in rivista - Articolo scientifico
Anti-HCV; hepatocellular carcinoma; cirrhosis;
English
183
187
5
Farinati, F., Fagiuoli, S., De Maria, N., Chiaramonte, M., Aneloni, V., Ongaro, S., et al. (1992). Anti-HCV positive hepatocellular carcinoma in cirrhosis. Prevalence, risk factors and clinical features. JOURNAL OF HEPATOLOGY, 14(2-3), 183-187 [10.1016/0168-8278(92)90156-j].
Farinati, F; Fagiuoli, S; De Maria, N; Chiaramonte, M; Aneloni, V; Ongaro, S; Salvagnini, M; Naccarato, R
File in questo prodotto:
File Dimensione Formato  
Farinati F. (1992) Anti HCV positive hepatocellular carinoma in cirrhosis.pdf

Solo gestori archivio

Dimensione 3.01 MB
Formato Adobe PDF
3.01 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/353221
Citazioni
  • Scopus 40
  • ???jsp.display-item.citation.isi??? 46
Social impact