To evaluate a new imaging technique, for diagnosis of prosthetic vascular graft infection. Avidin is a protein which accumulates nonspecifically at sites of inflammation or infection. Due to its extremely low dissociation constant with biotin sites of infection can be imaged, using avidin as a pre-target, followed by injection of 111In-labelled biotin. This technique is much simpler than the common scintigraphic methods which employ labelling of blood components and its target-to-background ratio is greater than the methods employing radiolabelled proteins.

Chiesa, R., Melissano, G., Castellano, R., Fernandez Zamora, C., Astore, D., Samuel, A., et al. (1995). Avidin and 111In-labelled biotin scan: a new radioisotopic method for localising vascular graft infection. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 10(4), 405-414 [10.1016/S1078-5884(05)80162-5].

Avidin and 111In-labelled biotin scan: a new radioisotopic method for localising vascular graft infection

CHIESA, ROBERT;FAZIO, FERRUCCIO;
1995

Abstract

To evaluate a new imaging technique, for diagnosis of prosthetic vascular graft infection. Avidin is a protein which accumulates nonspecifically at sites of inflammation or infection. Due to its extremely low dissociation constant with biotin sites of infection can be imaged, using avidin as a pre-target, followed by injection of 111In-labelled biotin. This technique is much simpler than the common scintigraphic methods which employ labelling of blood components and its target-to-background ratio is greater than the methods employing radiolabelled proteins.
Articolo in rivista - Articolo scientifico
Sensitivity and Specificity; Polyethylene Terephthalates; Tomography, Emission-Computed, Single-Photon; Polytetrafluoroethylene; Aorta; Humans; Popliteal Artery; Aged; Femoral Artery; Predictive Value of Tests; Prosthesis-Related Infections; Avidin; Indium Radioisotopes; Prospective Studies; Blood Vessel Prosthesis; Treatment Outcome; Prosthesis Design; Follow-Up Studies; Middle Aged; Biotin; Female; Iliac Artery; Male
English
1995
10
4
405
414
none
Chiesa, R., Melissano, G., Castellano, R., Fernandez Zamora, C., Astore, D., Samuel, A., et al. (1995). Avidin and 111In-labelled biotin scan: a new radioisotopic method for localising vascular graft infection. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 10(4), 405-414 [10.1016/S1078-5884(05)80162-5].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/35200
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