Objectives: To evaluate a new imaging technique, for diagnosis of prosthetic vascular graft infection. Avidin is a protein which accumulates nonspecifically at sites of inflammation or infection. Due to its extremely low dissociation constant with biotin sites of infection can be imaged, using avidin as a pre-target, followed by injection of 111In-labelled biotin. This technique is much simpler than the common scintigraphic methods which employ labelling of blood components and its target-to-background ratio is greater than the methods employing radiolabelled proteins. Design: Prospective clinical study. Setting: A single department of vascular surgery and one of nuclear medicine of a Northern Italian hospital. Materials: Between May 1993 and May 1994, 31 grafts in 26 patients were studied; the series included 23 men and three women with a mean age of 65.5 years (range 54-76 years). The prosthetic graft (Dacron-16, ePTFE-15) were: aortoaortic 5, aortobifemoral 15, aortoiliac 1, and fem...
Chiesa, R., Melissano, G., Castellano, R., Fernandez Zamora, C., Astore, D., Samuel, A., et al. (1995). Avidin and 111In-labelled biotin scan: a new radioisotopic method for localising vascular graft infection. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 10(4), 405-414 [10.1016/S1078-5884(05)80162-5].
Avidin and 111In-labelled biotin scan: a new radioisotopic method for localising vascular graft infection
CHIESA, ROBERT;FAZIO, FERRUCCIO;
1995
Abstract
Objectives: To evaluate a new imaging technique, for diagnosis of prosthetic vascular graft infection. Avidin is a protein which accumulates nonspecifically at sites of inflammation or infection. Due to its extremely low dissociation constant with biotin sites of infection can be imaged, using avidin as a pre-target, followed by injection of 111In-labelled biotin. This technique is much simpler than the common scintigraphic methods which employ labelling of blood components and its target-to-background ratio is greater than the methods employing radiolabelled proteins. Design: Prospective clinical study. Setting: A single department of vascular surgery and one of nuclear medicine of a Northern Italian hospital. Materials: Between May 1993 and May 1994, 31 grafts in 26 patients were studied; the series included 23 men and three women with a mean age of 65.5 years (range 54-76 years). The prosthetic graft (Dacron-16, ePTFE-15) were: aortoaortic 5, aortobifemoral 15, aortoiliac 1, and fem...I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.