Regional cerebral metabolism of glucose in comatose and vegetative state patients

Regional cerebral metabolism of glucose (rCMRglu) was evaluated in patients who were in a coma and vegetative state to determine the level of brain function during these conditions. rCMRglu was measured in 17 discrete brain regions with 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) and positron emission tomography (PET) in 15 patients with brain pathology subsequent to cardiorespiratory arrest (CA), head trauma (HT), or brain ischemia (BI) resulting from cerebrovascular accident or brain surgery. Five comatose patients (Coma group, n = 5), and 10 vegetative state patients (VS, patients awake but not aware) were studied. The VS patients were subdivided, according to the length of their VS condition, into a VS group (n = 6, <3 months if CA or BI patients, or <12 months if HT patients) and a persistent vegetative state group (PVS, n = 4, >3 months if CA or BI patients or >12 months if HT patients). Ten normal age-matched subjects served as control. Global CMRglu was 6.72 ± 0.93 (±SD) mg/100 g/mi...