The importance of glycosylation (post-translational attachment of glycan residues to proteins) in the context of neuroinflammation is only now beginning to be understood. Although the glycome is challenging to investigate due to its complexity, this field is gaining interest because of the emergence of novel analytical methods. These investigations offer the possibility of further understanding the molecular signature of disorders with underlying neuroinflammatory cascades. In this review, we portray the clinically relevant trends in glyconeurobiology and suggest glyco-related paths that could be targeted therapeutically to decrease neuroinflammation. A combinatorial insight from glycobiology and neurology can be harnessed to better understand neuroinflammatory-related conditions to identify relevant molecular targets.

Rebelo, A., Chevalier, M., Russo, L., Pandit, A. (2022). Role and therapeutic implications of protein glycosylation in neuroinflammation. TRENDS IN MOLECULAR MEDICINE, 28(4 (April 2022)), 270-289 [10.1016/j.molmed.2022.01.004].

Role and therapeutic implications of protein glycosylation in neuroinflammation

Russo L.;
2022

Abstract

The importance of glycosylation (post-translational attachment of glycan residues to proteins) in the context of neuroinflammation is only now beginning to be understood. Although the glycome is challenging to investigate due to its complexity, this field is gaining interest because of the emergence of novel analytical methods. These investigations offer the possibility of further understanding the molecular signature of disorders with underlying neuroinflammatory cascades. In this review, we portray the clinically relevant trends in glyconeurobiology and suggest glyco-related paths that could be targeted therapeutically to decrease neuroinflammation. A combinatorial insight from glycobiology and neurology can be harnessed to better understand neuroinflammatory-related conditions to identify relevant molecular targets.
Articolo in rivista - Articolo scientifico
brain; glycosylation; neurodegenerative diseases; neuroinflammation; spinal cord injury; traumatic brain injury;
English
270
289
20
Rebelo, A., Chevalier, M., Russo, L., Pandit, A. (2022). Role and therapeutic implications of protein glycosylation in neuroinflammation. TRENDS IN MOLECULAR MEDICINE, 28(4 (April 2022)), 270-289 [10.1016/j.molmed.2022.01.004].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/351590
Citazioni
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 2
Social impact