Peripheral-type benzodiazepine receptors were measured in human circulating lymphocytes using 3H-PK 11195 as specific ligand. In a group of outpatients with anxiety disorders a significant decrease of receptor density (-37%) was found compared with age-matched controls. In these patients long-term diazepam treatment restored binding density to normal levels: the effect persisted after drug withdrawal. Acute i.v. diazepam administration did not change receptor density. The observed receptor changes could reflect a down-regulation phenomenon and indicate that lymphocyte function reflect central nervous events.
Ferrarese, C., Appollonio, I., Frigo, M., Perego, M., Piolti, R., Trabucchi, M., et al. (1990). Decreased density of benzodiazepine receptors in lymphocytes of anxious patients: reversal after chronic diazepam treatment. ACTA PSYCHIATRICA SCANDINAVICA, 82(2), 169-173 [10.1111/j.1600-0447.1990.tb01376.x].
Decreased density of benzodiazepine receptors in lymphocytes of anxious patients: reversal after chronic diazepam treatment
FERRARESE, CARLO;APPOLLONIO, ILDEBRANDO;Frattola, L.
1990
Abstract
Peripheral-type benzodiazepine receptors were measured in human circulating lymphocytes using 3H-PK 11195 as specific ligand. In a group of outpatients with anxiety disorders a significant decrease of receptor density (-37%) was found compared with age-matched controls. In these patients long-term diazepam treatment restored binding density to normal levels: the effect persisted after drug withdrawal. Acute i.v. diazepam administration did not change receptor density. The observed receptor changes could reflect a down-regulation phenomenon and indicate that lymphocyte function reflect central nervous events.
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