Takayasu arteritis and primary sclerosing cholangitis are two rare disorders. The pathogenesis of Takayasu arteritis involves immune-mediated mechanisms, and corticosteroids represent the mainstay for treatment. Conversely, the aetiology of primary sclerosing cholangitis remains elusive, even if dysimmunity seems to be one of the contributors to bile duct damage. Despite this, immunosuppressants do not alter disease course. In this paper we describe the association of these two rare disorders, with an unexpected normalization of cholestatic enzymes following steroid treatment. This might hint a novel subtype of sclerosing cholangitis with a prevalent immunebackground, or a local manifestation of Takayasu arteritis.

Mulinacci, G., Palermo, A., Cristoferi, L., Invernizzi, P., Carbone, M. (2021). Takayasu arteritis and primary sclerosing cholangitis: A casual association or different phenotypes of the same disease?. JOURNAL OF TRANSLATIONAL AUTOIMMUNITY, 4 [10.1016/j.jtauto.2021.100124].

Takayasu arteritis and primary sclerosing cholangitis: A casual association or different phenotypes of the same disease?

Mulinacci G.;Palermo A.;Cristoferi L.;Invernizzi P.
;
Carbone M.
2021

Abstract

Takayasu arteritis and primary sclerosing cholangitis are two rare disorders. The pathogenesis of Takayasu arteritis involves immune-mediated mechanisms, and corticosteroids represent the mainstay for treatment. Conversely, the aetiology of primary sclerosing cholangitis remains elusive, even if dysimmunity seems to be one of the contributors to bile duct damage. Despite this, immunosuppressants do not alter disease course. In this paper we describe the association of these two rare disorders, with an unexpected normalization of cholestatic enzymes following steroid treatment. This might hint a novel subtype of sclerosing cholangitis with a prevalent immunebackground, or a local manifestation of Takayasu arteritis.
Articolo in rivista - Articolo scientifico
Inflammatory bowel disease; Primary sclerosing cholangitis; Takayasu arteritis; Vasculitis;
English
Mulinacci, G., Palermo, A., Cristoferi, L., Invernizzi, P., Carbone, M. (2021). Takayasu arteritis and primary sclerosing cholangitis: A casual association or different phenotypes of the same disease?. JOURNAL OF TRANSLATIONAL AUTOIMMUNITY, 4 [10.1016/j.jtauto.2021.100124].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/350919
Citazioni
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
Social impact