AIM: Whether obstructive sleep apnea (OSA) actually represents an independent risk factor for aortic dilation in the general population is unclear. We investigated this issue through a review and a meta-analysis of cardiac imaging studies that provided data on this vascular phenotype measured at the root or ascending tract level. DESIGN: A computerized search was performed using Pub-Med, OVID, EMBASE, and Cochrane library databases from inception up to 30 November 2021. Studies were identified by using the following search terms: "aortic root,""ascending aorta,""vascular damage,""echocardiography,""computed tomography,""magnetic resonance imaging,""obstructive sleep apnea,""sleep disordered breathing."RESULTS: Eleven studies including a total of 1,860 patients with OSA (without aortic aneurysms and connective tissue diseases) and 233 non-OSA controls were considered. Aortic diameter was significantly higher in patients with OSA than in non-OSA controls (standard means difference [SMD] = 0.73 ± 0.08, confidence interval [CI]: 0.57-0.88, P < 0.0001). This was also the case for patients with severe OSA as compared with their counterparts with mild OSA (SMD = 0.42 ± 0.07, CI: 0.28-0.56, P < 0.0001). CONCLUSIONS: Our findings suggest an association between OSA and aortic enlargement and particularly in the severe OSA setting. However, this conclusion must be taken with caution in relation to 2 types of factors: (i) the paucity of available data, and (ii) the limits deriving from the methodological differences of the various studies. Larger prospective and carefully designed studies are needed to shed light on this relevant public health topic.

Gherbesi, E., Tadic, M., Faggianoa, A., Sala, C., Carugo, S., Cuspidi, C. (2022). Sleep Apnea Syndrome And Large Artery Subclinical Damage: Targeting Thoracic Aortic Dilatation. AMERICAN JOURNAL OF HYPERTENSION, 35(6), 543-550 [10.1093/ajh/hpac006].

Sleep Apnea Syndrome And Large Artery Subclinical Damage: Targeting Thoracic Aortic Dilatation

Cesare Cuspidi
2022

Abstract

AIM: Whether obstructive sleep apnea (OSA) actually represents an independent risk factor for aortic dilation in the general population is unclear. We investigated this issue through a review and a meta-analysis of cardiac imaging studies that provided data on this vascular phenotype measured at the root or ascending tract level. DESIGN: A computerized search was performed using Pub-Med, OVID, EMBASE, and Cochrane library databases from inception up to 30 November 2021. Studies were identified by using the following search terms: "aortic root,""ascending aorta,""vascular damage,""echocardiography,""computed tomography,""magnetic resonance imaging,""obstructive sleep apnea,""sleep disordered breathing."RESULTS: Eleven studies including a total of 1,860 patients with OSA (without aortic aneurysms and connective tissue diseases) and 233 non-OSA controls were considered. Aortic diameter was significantly higher in patients with OSA than in non-OSA controls (standard means difference [SMD] = 0.73 ± 0.08, confidence interval [CI]: 0.57-0.88, P < 0.0001). This was also the case for patients with severe OSA as compared with their counterparts with mild OSA (SMD = 0.42 ± 0.07, CI: 0.28-0.56, P < 0.0001). CONCLUSIONS: Our findings suggest an association between OSA and aortic enlargement and particularly in the severe OSA setting. However, this conclusion must be taken with caution in relation to 2 types of factors: (i) the paucity of available data, and (ii) the limits deriving from the methodological differences of the various studies. Larger prospective and carefully designed studies are needed to shed light on this relevant public health topic.
Articolo in rivista - Articolo scientifico
aortic diameter; blood pressure; general population; hypertension; sleep apnea syndrome;
English
2022
543
550
8
Gherbesi, E., Tadic, M., Faggianoa, A., Sala, C., Carugo, S., Cuspidi, C. (2022). Sleep Apnea Syndrome And Large Artery Subclinical Damage: Targeting Thoracic Aortic Dilatation. AMERICAN JOURNAL OF HYPERTENSION, 35(6), 543-550 [10.1093/ajh/hpac006].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/350198
Citazioni
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
Social impact