Diazepam binding inhibitor (DBI) is a novel neuropeptide purified from rat, cow, and human brain that allosterically modulates GABAergic transmission by binding to benzodiazepine (BDZ)-recognition sites. Using a specific radioimmunoassay for human DBI, we investigated the distribution of this peptide in different brain areas. We characterized with high-pressure liquid chromatography the DBI immunoreactivity in brain tissue obtained by biopsy and autopsy; we detected one molecular species of DBI in both instances. The regional distribution of DBI in the human brain is similar to that observed in rat brain: high concentrations in cortical and limbic areas, cerebellum, and brainstem, and low concentrations in the basal ganglia. These data suggest a modulatory role for DBI in human brain.

Ferrarese, C., Appollonio, I., Frigo, M., Piolti, R., Tamma, F., & Frattola, L. (1989). Distribution of a putative endogenous modulator of the GABAergic system in human brain. NEUROLOGY, 39(3), 443-445 [10.1212/WNL.39.3.443].

Distribution of a putative endogenous modulator of the GABAergic system in human brain

Ferrarese, C;Appollonio, I;
1989

Abstract

Diazepam binding inhibitor (DBI) is a novel neuropeptide purified from rat, cow, and human brain that allosterically modulates GABAergic transmission by binding to benzodiazepine (BDZ)-recognition sites. Using a specific radioimmunoassay for human DBI, we investigated the distribution of this peptide in different brain areas. We characterized with high-pressure liquid chromatography the DBI immunoreactivity in brain tissue obtained by biopsy and autopsy; we detected one molecular species of DBI in both instances. The regional distribution of DBI in the human brain is similar to that observed in rat brain: high concentrations in cortical and limbic areas, cerebellum, and brainstem, and low concentrations in the basal ganglia. These data suggest a modulatory role for DBI in human brain.
Articolo in rivista - Articolo scientifico
Scientifica
gamma-Aminobutyric Acid; Diazepam Binding Inhibitor; Humans; Brain Chemistry; Brain; Tissue Distribution; Neuropeptides
English
Ferrarese, C., Appollonio, I., Frigo, M., Piolti, R., Tamma, F., & Frattola, L. (1989). Distribution of a putative endogenous modulator of the GABAergic system in human brain. NEUROLOGY, 39(3), 443-445 [10.1212/WNL.39.3.443].
Ferrarese, C; Appollonio, I; Frigo, M; Piolti, R; Tamma, F; Frattola, L
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/34921
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