Ex vivo gene expression and miRNA profiling of Eomes+ Tr1-like cells suggested that they represent a differentiation stage that is intermediate between Th1-cells and cytotoxic CD4+ T-cells. Several microRNAs were downregulated in Eomes+ Tr1-like cells that might inhibit Tr1-cell differentiation. In particular, miR-92a targeted Eomes, while miR-125a inhibited IFN-g and IL-10R expression.

De Simone, M., Chirichella, M., Emming, S., Mazzara, S., Ranzani, V., Gruarin, P., et al. (2021). Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R. EUROPEAN JOURNAL OF IMMUNOLOGY, 51(12), 3243-3246 [10.1002/eji.202149315].

Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R

Ranzani V.;Pulvirenti N.;
2021

Abstract

Ex vivo gene expression and miRNA profiling of Eomes+ Tr1-like cells suggested that they represent a differentiation stage that is intermediate between Th1-cells and cytotoxic CD4+ T-cells. Several microRNAs were downregulated in Eomes+ Tr1-like cells that might inhibit Tr1-cell differentiation. In particular, miR-92a targeted Eomes, while miR-125a inhibited IFN-g and IL-10R expression.
Lettera in rivista
EOMES; IL-10R; microRNAs; Tr1-like cells;
English
3243
3246
4
De Simone, M., Chirichella, M., Emming, S., Mazzara, S., Ranzani, V., Gruarin, P., et al. (2021). Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R. EUROPEAN JOURNAL OF IMMUNOLOGY, 51(12), 3243-3246 [10.1002/eji.202149315].
File in questo prodotto:
File Dimensione Formato  
EJi_2021_microRNA.pdf

Solo gestori archivio

Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Dimensione 1.89 MB
Formato Adobe PDF
1.89 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/348844
Citazioni
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
Social impact