Ex vivo gene expression and miRNA profiling of Eomes+ Tr1-like cells suggested that they represent a differentiation stage that is intermediate between Th1-cells and cytotoxic CD4+ T-cells. Several microRNAs were downregulated in Eomes+ Tr1-like cells that might inhibit Tr1-cell differentiation. In particular, miR-92a targeted Eomes, while miR-125a inhibited IFN-g and IL-10R expression.

De Simone, M., Chirichella, M., Emming, S., Mazzara, S., Ranzani, V., Gruarin, P., et al. (2021). Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R. EUROPEAN JOURNAL OF IMMUNOLOGY, 51(12), 3243-3246 [10.1002/eji.202149315].

Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R

Ranzani V.;Pulvirenti N.;
2021

Abstract

Ex vivo gene expression and miRNA profiling of Eomes+ Tr1-like cells suggested that they represent a differentiation stage that is intermediate between Th1-cells and cytotoxic CD4+ T-cells. Several microRNAs were downregulated in Eomes+ Tr1-like cells that might inhibit Tr1-cell differentiation. In particular, miR-92a targeted Eomes, while miR-125a inhibited IFN-g and IL-10R expression.
Lettera in rivista
EOMES; IL-10R; microRNAs; Tr1-like cells;
English
2021
51
12
3243
3246
reserved
De Simone, M., Chirichella, M., Emming, S., Mazzara, S., Ranzani, V., Gruarin, P., et al. (2021). Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R. EUROPEAN JOURNAL OF IMMUNOLOGY, 51(12), 3243-3246 [10.1002/eji.202149315].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/348844
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